Evidence map›Paper›PMID 40938513›Full record

ReviewJournal of molecular histology2025

BRAF mutations in ovarian cancer: immune microenvironment and therapeutic advances.

Yuhang Wang, Xue Du

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yuhang WangGraduate School, Tianjin Medical University, Tianjin, 300070, China.
Xue DuDepartment of Gynecology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Jieyuan Road 190, Hongqiao District, Tianjin, 300121, China. duxue_nku@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer is a highly lethal malignancy of the female reproductive system, characterized by a poor prognosis and complex therapeutic challenges influenced by various molecular and microenvironmental factors. Among these, mutations in the BRAF gene have received increasing attention across multiple malignancies due to their involvement in oncogenic signaling pathways and implications for targeted therapy. Concurrently, the tumor immune microenvironment has been recognized as a critical determinant in the initiation and progression of tumors. This review explores the impact of BRAF mutations on the immune microenvironment in ovarian cancer, summarizes recent advances in the field, and assesses the potential clinical significance of these findings in informing therapeutic strategies. Clinical trial number: Not applicable.

Indexed as

MutationOvarian NeoplasmsProto-Oncogene Proteins B-rafTumor MicroenvironmentAnimalsFemaleHumansMolecular Targeted TherapySignal TransductionBRAF protein, humanProto-Oncogene Proteins B-rafBRAF geneOvarian cancerTreatment strategiesTumor immunityTumor microenvironment

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.