Evidence map›Paper›PMID 40938511›Full record

ArticleMolecular diversity2026

Synthesis of novel phthalide bearing thiazole, 1,3,4-oxadiazole, and oxime ether groups as potential antifungal agents.

Yong Li, Taotao Wu, Guobin Chen, Jian He, Yong Zhang, Qin Zhang, Pengfei Zhou, Wenzhang Chen, Lingling Fan

Abstract read
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In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yong Li *State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &, School of Pharmaceutical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, 550004, People's Republic of China.
Taotao Wu *State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &, School of Pharmaceutical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, 550004, People's Republic of China.
Guobin ChenState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &, School of Pharmaceutical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, 550004, People's Republic of China.
Jian HeState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &, School of Pharmaceutical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, 550004, People's Republic of China.
Yong ZhangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &, School of Pharmaceutical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, 550004, People's Republic of China.
Qin ZhangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &, School of Pharmaceutical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, 550004, People's Republic of China.
Pengfei ZhouState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &, School of Pharmaceutical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, 550004, People's Republic of China.
Wenzhang ChenState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &, School of Pharmaceutical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, 550004, People's Republic of China.
Lingling FanState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &, School of Pharmaceutical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, 550004, People's Republic of China. fanling1025@126.com.

Funding

Guizhou Medical University High-Level Talents Research Initiation Fund Project XiaoboheJzi[2024]031Guizhou Provincial Natural Science Foundation QKHJC-ZK[2023]YIBAN309Science and Technology Fund Project of Guizhou Provincial Health Commission gzwkj2025-137The National Natural Science Foundation of China No.22207021 and No.32060627
6 · The paper itself

Abstract

Twenty-eight novel phthalide derivatives incorporating thiazole, 1,3,4-oxadiazole, and oxime ether moieties were designed and synthesized using a pharmacophore hybridization strategy. Bioactivity assays demonstrated that compounds 1b, 1c, 4a, 4b and 4c exhibited moderate to excellent inhibitory activity against several specific fungi. Notably, compound 1b displayed superior antifungal efficacy against F. solani, F. oxysporum, B. dothidea, and V. mali compared to the commercial fungicides hymexazol and boscalid, with EC

Indexed as

Antifungal AgentsBenzofuransOxadiazolesOximesThiazolesChemistry Techniques, SyntheticEthersFungiMicrobial Sensitivity TestsStructure-Activity Relationship1,3,4-oxadiazoleAntifungal AgentsBenzofuransEthersOxadiazolesOximesphthalideThiazoles1,3,4-oxadiazoleAntifungal activityOxime etherPhthalideThiazole

Identifiers

PMID40938511

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.