Evidence map›Paper›PMID 40938506›Full record

ArticleJournal of medical systems2025

Bimodal ECG and PCG Cardiovascular Disease Detection: Exploring the Potential and Modality Contribution.

Alessia Calzoni, Mattia Savardi, Marco Silvestri, Sergio Benini, Alberto Signoroni

Abstract read
In one paragraph

Article in Journal of medical systems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Cross-cohort Generalization for Heart Disease Prediction with Explainable AI.Journal of cardiovascular translational research · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alessia CalzoniUniversity of Brescia, Department of Information Engineering, Via Branze 38, Brescia, 25123, Italy. alessia.calzoni@unibs.it.
Mattia SavardiDepartment of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Viale Europa 11, Brescia, 25121, Lombardia, Italy.
Marco SilvestriIsinnova srl, Via Berlinguer 2, Brescia, 25124, Italy.
Sergio BeniniUniversity of Brescia, Department of Information Engineering, Via Branze 38, Brescia, 25123, Italy.
Alberto SignoroniDepartment of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Viale Europa 11, Brescia, 25121, Lombardia, Italy.

Funding

Italian Ministry of Research 2022A49KR3
6 · The paper itself

Abstract

Early detection of cardiovascular diseases (CVDs) is crucial for improving patient outcomes and alleviating healthcare burdens. Electrocardiograms (ECGs) and phonocardiograms (PCGs) offer low-cost, non-invasive, and easily integrable solutions for preventive care settings. In this work, we propose a novel bimodal deep learning model that combines ECG and PCG signals to enhance the early detection of CVDs. To address the challenge of limited bimodal data, we fine-tuned a Convolutional Neural Network (CNN) pre-trained on large-scale audio recordings, leveraging all publicly available unimodal PCG datasets. This PCG branch was then integrated with a 1D-CNN ECG branch via late fusion. Evaluated on an augmented version of MITHSDB, currently the only publicly available bimodal dataset, our approach achieved an AUROC of 96.4%, significantly outperforming ECG-only and PCG-only models by approximately 3%pts and 11%pts, respectively. To interpret the model's decisions, we applied three explainability techniques, quantifying the relative contributions of the electrical and acoustic features. Furthermore, by projecting the learned embeddings into two dimensions using UMAP, we revealed clear separation between normal and pathological samples. Our results conclusively demonstrate that combining ECG and PCG modalities yields substantial performance gains, with explainability and visualization providing critical insights into model behavior. These findings underscore the importance of multimodal approaches for CVDs diagnosis and prevention, and strongly motivate the collection of larger, more diverse bimodal datasets for future research.

Indexed as

Cardiovascular DiseasesDeep LearningElectrocardiographyEarly DiagnosisHumansNeural Networks, ComputerPhonocardiographySignal Processing, Computer-AssistedBimodal learningCardiovascular diseasesElectrocardiogramExplainabilityMultimodal fusionPhonocardiogramTransfer learning

Identifiers

PMID40938506
PMCPMC12432067

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.