Evidence map›Paper›PMID 40938495›Full record

ArticleCancer causes & control : CCC2025

Impact of neighbor-level disadvantage on survival outcomes in head and neck squamous cell carcinoma.

William J Benjamin, Siddhi Patil, Elham Mohebbi, Sophia Latif, Chamila Perera, Emily Bellile, Kai Wang, Maureen A Sartor, Jeremy M G Taylor, Gregory T Wolf and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

William J BenjaminDepartment of Otolaryngology - Head and Neck Surgery, Mass Eye and Ear, Boston, MA, USA.
Siddhi PatilDepartment of Oncology, Georgetown University, 2115 Wisconsin Ave NW, Washington, DC, 20007, USA.
Elham MohebbiDepartment of Oncology, Georgetown University, 2115 Wisconsin Ave NW, Washington, DC, 20007, USA.
Sophia LatifMilken Institute of Public Health, George Washington University, Washington, DC, USA.
Chamila PereraDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Emily BellileDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Kai WangDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Maureen A SartorDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Jeremy M G TaylorDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Gregory T WolfDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
Steven B ChinnDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
Laura S RozekDepartment of Oncology, Georgetown University, 2115 Wisconsin Ave NW, Washington, DC, 20007, USA. lr898@georgetown.edu.

Funding

Therapeutic Potential and Mechanism of Action of Potent Small Molecule InhibitorsP50CA097248 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NOR, JACQUES EDUARDO · 2002 to 2013
$25.3M
Downstream effects of HPV integration on survival/metastasis in oropharyngeal cancerR01CA250214 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI D'SILVA, NISHA J, ROZEK, LAURA · 2020 to 2024
$3.1M
NCI NIH HHS P50 CA097248NCI NIH HHS R01 CA250214NIH HHS P50CA097248
6 · The paper itself

Abstract

purposeTo assess the impact of neighborhood-level disadvantage using the area disadvantage index (ADI) on survival outcomes in head and neck squamous cell carcinoma (HNSCC) patients.

methodsPatients diagnosed with previously untreated HNSCC from a single institutional study at a large, tertiary care hospital between 2008 and 2014 were provided self-administered questionnaires in a prospective longitudinal cohort study. Area Deprivation Index (ADI) was the primary exposure of interest, calculated using Federal Information Processing Standard (FIPS) codes that assess a neighborhood's socioeconomic conditions, where a higher ADI indicates a disadvantaged neighborhood and lower socioeconomic status. The primary outcomes of interest were overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS). Survival outcomes were assessed using Kaplan-Meier analysis and Cox proportional hazard models.

resultsThe study included 792 patients. Patients with a higher ADI score were more likely to live in a less populous area (p < 0.01) and have a higher comorbidity score (p < 0.01), were heavy smokers (p < 0.01), and most cases (80.8%) tested negative for Human Papillomavirus (HPV) infection (p < 0.01). Higher terciles of ADI were associated with lower 5-year OS (p < 0.01), DSS (p = 0.01), and RFS (p = 0.03), with each 10-point increase in ADI being associated with a 1.1 times increase in hazard of death, disease-specific death, or recurrence (p < 0.01 for all). Patients in the highest tercile of ADI had significantly higher hazards of death (HR: 1.8 [1.3, 2.4], p < 0.01) and recurrence (1.4 [1.1, 1.9], p = 0.04) compared to the lowest tercile. In multivariable models, ADI was not significantly associated with OS, DSS, or RFS. Predictors of OS and DSS included HPV, stage, age, BMI, pack years, and comorbidity score, while RFS was predicted by HPV, stage, and comorbidity.

conclusionsHigher ADI scores were linked to poorer survival outcomes in HNSCC. These findings underscore the importance of considering social determinants of health, particularly ADI components like income, employment, housing quality, and access to care, in influencing HNSCC mortality and recurrence rates.

Indexed as

Head and Neck NeoplasmsNeighborhood CharacteristicsSquamous Cell Carcinoma of Head and NeckAdultAgedFemaleHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesSocioeconomic FactorsArea deprivation indexHead and Neck CancerNeighborhood-level deprivationSurvival

Identifiers

PMID40938495
PMCPMC12630178

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.