Evidence map›Paper›PMID 40938464›Full record

ReviewMolecular biology reports2025

The functions and regulation of transcription factor YBX1 in cancers.

Aixin Qiu, Yue Zhang, Yihan Dong, Dan Yue, Yang Yu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aixin Qiu *Department of Urology, The Second Hospital of Dalian Medical University, Dalian, 116023, China.
Yue Zhang *Department of Urology, The Second Hospital of Dalian Medical University, Dalian, 116023, China.
Yihan DongSchool of Medical Technology, Tianjin Medical University, Tianjin, 300203, China.
Dan YueSchool of Medical Technology, Tianjin Medical University, Tianjin, 300203, China.
Yang YuDepartment of Urology, The Second Hospital of Dalian Medical University, Dalian, 116023, China. 17709871980@163.com.

Funding

Liaoning Provincial Science and Technology Plan Project-General Project of the Joint Fund Project of Liaoning Provincial Science and Technology Plan 2024-MSLH-108the "1+X" program for Clinical Competency enhancement-Clinical Research Incubation Project of the Second Hospital of Dalian Medical University 2022LCYJZD02
6 · The paper itself

Abstract

YBX1 is a DNA-binding and RNA-binding protein notable for its evolutionarily conserved cold shock domain. It is located in both the cytoplasm and nucleus and participates in various biological processes, including pre-mRNA splicing, transcription, translation, DNA damage repair, and mRNA stability. Moreover, YBX1 exhibits elevated expression levels across multiple malignancies, and its nuclear translocation is associated with poor cancer prognosis and disease progression. Therefore, elucidating the underlying regulatory mechanisms of YBX1 and its oncogenic role in driving cancer progression is of paramount importance. This review summarizes the diverse physiological functions of YBX1, highlighting its roles and how YBX1 function in various malignancies.

Indexed as

NeoplasmsY-Box-Binding Protein 1AnimalsCell NucleusDNA RepairGene Expression Regulation, NeoplasticHumansRNA SplicingY-Box-Binding Protein 1YBX1 protein, humanBiomarkersCancerPost-translational modificationTranscription factorYBX1

Identifiers

PMID40938464

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.