ReviewCurrent nutrition reports2025
Molecular Mechanisms, Physiological Effects, Gut Microbiota Interplay and Nutritional Strategies of Anthocyanins as Modulators of Muscle Protein Synthesis: A Narrative Review.
Review in Current nutrition reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Effects of dietary mulberry anthocyanins on meat quality, antioxidant capacity, gut microbiota, and plasma anthocyanin exposure in North China Chai chickens.Poultry science · 2026Article
- Beyond Antioxidants: The Microbial Metabolic Landscape of Anthocyanins and Their Downstream Health Implications.Nutrients · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
purpose of reviewIn this review we examine the role of anthocyanins-bioactive flavonoids found in colorful fruits and vegetables-in modulating muscle protein synthesis (MPS). We aim to elucidate the underlying molecular mechanisms, including the activation of anabolic pathways such as PI3K/Akt/mTOR and AMPK, while also highlighting the influence of gut microbiota on anthocyanin bioavailability and subsequent muscle metabolic responses. The goal is to provide nutritionists, clinicians, and sports scientists with a comprehensive understanding of how anthocyanins can be leveraged to enhance muscle recovery, attenuate sarcopenia, and optimize exercise performance. RECENT
findingsAnthocyanins can stimulate key signaling cascades associated with MPS, notably by enhancing the phosphorylation of mTOR and its downstream effectors, thereby promoting protein translation and muscle repair. Clinical and preclinical evidence suggests that these compounds not only reduce exercise-induced muscle damage and inflammation but also improve insulin sensitivity and anabolic signaling. Furthermore, interactions with the gut microbiota result in the formation of bioactive metabolites that may further augment the muscle protein synthesis process. Despite these promising results, challenges remain regarding optimal dosing, bioavailability, and interindividual variability in response to supplementation. The review consolidates current evidence positioning anthocyanins as promising dietary bioactives for muscle health. Their dual role in modulating both direct molecular pathways and gut microbiota interactions underscores their potential in enhancing muscle protein synthesis and recovery. However, further research is essential to standardize supplementation protocols, improve bioavailability, and fully understand the synergistic effects of other nutrients. These insights pave the way for targeted nutritional strategies aimed at improving muscle function and mitigating age-related muscle decline.
Indexed as
Identifiers
40938456What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.