Evidence map›Paper›PMID 40938435›Full record

ArticlePediatric radiology2025

Comparison of phase-resolved functional lung (PREFUL) and hyperpolarized

Samal Munidasa, Faiyza Alam, Brandon Zanette, Daniel Li, Wallace Wee, Sharon Braganza, Jason Woods, Felix Ratjen, Giles Santyr

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Pediatric radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samal MunidasaTranslational Medicine, Hospital for Sick Children, 686 Bay St., Toronto, ON M5G 0A4, Canada. samal.munidasa@cchmc.org.
Faiyza AlamTranslational Medicine, Hospital for Sick Children, 686 Bay St., Toronto, ON M5G 0A4, Canada.
Brandon ZanetteTranslational Medicine, Hospital for Sick Children, 686 Bay St., Toronto, ON M5G 0A4, Canada.
Daniel LiTranslational Medicine, Hospital for Sick Children, 686 Bay St., Toronto, ON M5G 0A4, Canada.
Wallace WeeDivision of Respiratory Medicine, Hospital for Sick Children, Toronto, Canada.
Sharon BraganzaTranslational Medicine, Hospital for Sick Children, 686 Bay St., Toronto, ON M5G 0A4, Canada.
Jason WoodsPulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, USA.
Felix RatjenTranslational Medicine, Hospital for Sick Children, 686 Bay St., Toronto, ON M5G 0A4, Canada.
Giles SantyrTranslational Medicine, Hospital for Sick Children, 686 Bay St., Toronto, ON M5G 0A4, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhase-resolved functional lung (PREFUL) MRI offers a more accessible alternative to hyperpolarized

objectiveTo assess longitudinal lung function changes following elexacaftor/tezacaftor/ivacaftor (ETI) treatment initiation in CF children using PREFUL MRI, in comparison with Xe-MRI and pulmonary function tests (PFTs). MATERIALS AND

methodsPREFUL MRI, Xe-MRI, and PFTs were performed in 14 CF patients (median [IQR] age 15 [14-16.5] years old) at baseline and 1 month, 6 months, 12 months, and 24 months following initiation of ETI treatment. Ventilation and defect percentage (VDP) was derived from PREFUL MRI (regional ventilation VDP, VDP

resultsAll PREFUL measures significantly improved (P < 0.01) 1-month post-treatment in agreement with changes in Xe-MRI VDP and PFTs (P < 0.03). The absolute change in VDP

conclusionPREFUL MRI detects longitudinal treatment-related changes in pulmonary ventilation and perfusion in CF children post ETI.

Indexed as

AminophenolsBenzodioxolesCystic FibrosisMagnetic Resonance ImagingQuinolonesAdolescentDrug CombinationsFemaleHumansIndolesLongitudinal StudiesLungMalePyrazolesPyridinesPyrrolidinesAminophenolsBenzodioxolesDrug Combinationselexacaftorelexacaftor, ivacaftor, tezacaftor drug combinationIndolesPyrazolesPyridinesPyrrolidinesQuinolinesQuinolonesXenon-129Xenon IsotopesCystic fibrosisHyperpolarized xenon gasMagnetic resonance imagingModulator therapyPhase-resolved functional lungPulmonary ventilation and perfusion

Identifiers

PMID40938435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.