SynthesisNeuroradiology2025
Resting-state functional MRI activity and connectivity in inflammatory bowel disease: a systematic review.
Synthesis in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mapping the neuroimaging landscape of inflammatory bowel disease: a bibliometric analysis and systematic scoping review.Frontiers in neuroscience · 2026Pooled it
- From abstract to article: Publication outcomes of oral presentations at the ESNR congresses between 2018 and 2022.Neuroradiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeInflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), primarily affects the gastrointestinal tract but can also present with systemic manifestations, including those affecting the central nervous system (CNS). Resting-state functional MRI (rs-fMRI) provides insights into alterations in brain activity and connectivity. This review aims to evaluate rs-fMRI findings in IBD patients compared to healthy controls and to explore potential differences between CD and UC.
methodsA systematic search of PubMed/MEDLINE and SCOPUS identified rs-fMRI studies in neurologically asymptomatic IBD patients. Observational rs-fMRI studies assessing local neural activity and/or functional connectivity, were included.
resultsTwenty-seven studies met eligibility criteria and findings were summarized descriptively based on rs-fMRI analysis technique, given the methodological variability. UC patients showed reduced neural activity in the hippocampus and altered functional connectivity in the visual and cerebellar networks, highlighting memory and motor control disruptions. CD patients exhibited increased neural activity in the anterior cingulate cortex and frontal regions, alongside altered connectivity in multiple sensory and higher-order cognitive networks. Both IBD types displayed disruptions in key networks, including the default mode, salience, and cerebellar networks, associated with emotional processing, pain perception and stress response regulation.
conclusionDespite shared rs-fMRI disruptions, UC is primarily associated with decreased neural activity in areas linked to memory and motor coordination, whereas CD exhibits increased activity in regions regulating emotion and cognition. Connectivity disruptions underscore the broader impact of IBD on brain function, emphasizing the role of the brain-gut axis in emotional and sensory impairments.
Indexed as
Identifiers
40938374What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.