Evidence map›Paper›PMID 40938350›Full record

ArticleInternal and emergency medicine2025

Management of bile acid diarrhea in Italy: a survey.

Giovanni Marasco, Giovanni Barbara, Massimo Bellini, Piero Portincasa, Vincenzo Stanghellini, Bruno Annibale, Antonio Benedetti, Giovanni Cammarota, Walter Fries, Paolo Usai Satta and 1 more

Abstract read
In one paragraph

Article in Internal and emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Giovanni MarascoIRCCS Azienda Ospedaliero Universitaria Di Bologna, Bologna, Italy. giovanni.marasco4@unibo.it.ORCID 0000-0001-7167-8773
Giovanni BarbaraIRCCS Azienda Ospedaliero Universitaria Di Bologna, Bologna, Italy.
Massimo BelliniGastrointestinal Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Piero PortincasaClinica Medica "A. Murri", Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari Aldo Moro, Bari, Italy.
Vincenzo StanghelliniDepartment of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Bruno AnnibaleDepartment of Medical-Surgical Sciences and Translational Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Antonio BenedettiClinic of Gastroenterology and Hepatology, Università Politecnica Delle Marche, Ospedali Riuniti-University Hospital, Ancona, Italy.
Giovanni CammarotaGastroenterology Unit, Fondazione Policlinico A Gemelli IRCCS, Catholic University of Medicine, Rome, Italy.
Walter FriesClinical Unit of Gastroenterology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Paolo Usai SattaGastroenterology Unit, ARNAS G. Brotzu, Cagliari, Italy.
Enrico Stefano CorazziariDepartment of Gastroenterology, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bile acid diarrhea (BAD) is a common, under-investigated cause of chronic diarrhea. We aimed to assess the current management of BAD among a group of Italian physicians. A survey was developed by a task force of experts and distributed via the Internet to Italian physicians members of the main Italian gastroenterological associations. Ninety-four physicians accepted to participate, of whom 44% were females. The majority of participants were gastroenterologists (63%) and the mean age was 50.5 years. No differences in the rate of BAD diagnosis among patients with chronic diarrhea were found according to medical specialization. Gastroenterologists reported a higher prevalence of BAD compared with other physicians/general practitioners (1% vs 0.3%). BAD suspicion is mostly raised in the presence of watery stools and > 3 bowel movements/day and the exclusion of organic/drug-related diseases. BAD diagnosis was assessed with 75SeHCAT (67.8% of gastroenterologists and 51.4% of other physicians), followed by a trial of cholestyramine (30.5% of gastroenterologists and 31.4% of other physicians). Therapies most prescribed for BAD were cholestyramine, a low-fat diet, and stool thickeners. BAD is a common condition generally suspected in the presence of chronic watery diarrhea. 75SeHCAT availability influences the awareness of this disease. Therapies currently are often not able to guarantee adequate symptom relief.

Indexed as

Bile Acids and SaltsDiarrheaAdultCholestyramine ResinFemaleHumansItalyMaleMiddle AgedPractice Patterns, Physicians'Surveys and QuestionnairesBile Acids and SaltsCholestyramine ResinBile acid diarrheaCholestyramineColesevelamDiarrheaIrritable bowel syndromeSurvey

Identifiers

PMID40938350
PMCPMC12534326

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.