Evidence map›Paper›PMID 40938339›Full record

ArticleMolecular imaging and biology2025

Effects of Age and BMI on Histamine H3 Receptor Availability in Healthy Humans.

Yanghong Yang, Waleed Ibrahim, Paul Gravel, Brian Pittman, Jocelyn Hoye, Ryan Cool, Faranak Ebrahimian Sadabad, Ming-Qiang Zheng, Christopher Pittenger, Jean-Dominique Gallezot and 4 more

Abstract read
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In one paragraph

Article in Molecular imaging and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yanghong YangDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA. yanghong.yang@yale.edu.ORCID 0000-0002-6816-1252
Waleed IbrahimDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Paul GravelDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Brian PittmanDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Jocelyn HoyeDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Ryan CoolDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Faranak Ebrahimian SadabadDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Ming-Qiang ZhengDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Christopher PittengerDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Jean-Dominique GallezotDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Richard E CarsonDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Henry HuangDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Rajiv RadhakrishnanDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
David MatuskeyDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess alterations in H3R availability with age and body mass index (BMI) in healthy humans using in vivo [ PROCEDURE: Twenty-four healthy individuals (2 females, 22 males; age range 20-47 years) were scanned with [

resultsH3R availability (V

conclusionThis in vivo H3R study found a significant age-related decline in most cortical and subcortical regions.

Indexed as

AgingBody Mass IndexReceptors, Histamine H3AdultAge FactorsBrainCarbon RadioisotopesFemaleHealthy VolunteersHumansMaleMiddle AgedPositron-Emission TomographyYoung AdultCarbon RadioisotopesReceptors, Histamine H3[11C] GSK189254AgingHistamine H3 ReceptorPET imaging

Identifiers

PMID40938339

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.