Evidence map›Paper›PMID 40938212›Full record

ArticleAdvanced biology2025

Loss of Stat3 in Prx1

Xin Feng, Wangyu Luo, Yichen Yao, Lichieh Lin, Laiting Chan, Jiarui Lu, Zijing Huang, Jingyi Feng, Le Zhao, Xiaolei Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Loss of Stat3 in Prx1Advanced biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xin FengGuangdong Province Key Laboratory of Stomatology, Guanghua School and Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055, China.
Wangyu LuoDepartment of Stomatology, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518033, China.
Yichen YaoGuangdong Province Key Laboratory of Stomatology, Guanghua School and Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055, China.
Lichieh LinDepartment of Stomatology, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518033, China.
Laiting ChanGuangdong Province Key Laboratory of Stomatology, Guanghua School and Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055, China.
Jiarui LuDepartment of Stomatology, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518033, China.
Zijing HuangStomatological Hospital, Southern Medical University, Guangzhou, Guangdong, 510280, China.
Jingyi FengDepartment of Stomatology, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518033, China.
Le ZhaoDepartment of Stomatology, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518033, China.
Xiaolei ZhangDepartment of Stomatology, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518033, China.ORCID 0000-0003-2410-179X
Liu YangDepartment of Stomatology, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518033, China.ORCID 0000-0001-8511-4493

Funding

Futian Healthcare Research Project FTWS2022006National Natural Science Foundation of China 81470731National Natural Science Foundation of China 82000996Shenzhen Clinical Research Center for Oral Diseases Project 20210617170745001Shenzhen Science and Technology Program JCYJ20220530144410023Shenzhen Science and Technology Program JCYJ20220530144410024Shenzhen Science and Technology Program JCYJ20230807110959035
6 · The paper itself

Abstract

Signal Transducer and Activator of Transcription 3 (Stat3) acts as a central transcriptional modulator coordinating cellular proliferation, survival, apoptosis, vascularization, immune regulation, and migratory processes. Human Stat3 deficiency triggers Hyper-IgE syndrome, associated with immune dysregulation, osseous defects, and dental malformations. This study employs genetically engineered murine models to dissect Stat3's mechanistic role within mesenchymal progenitor cells during molar root formation and periodontal tissue maturation. Conditional Stat3 knockout mice (Prx1-Cre; Stat3

Indexed as

Homeodomain ProteinsMesenchymal Stem CellsMolarOdontogenesisSTAT3 Transcription FactorTooth RootAnimalsCell ProliferationMiceMice, KnockoutOsteogenesisPeriodontal LigamentHomeodomain ProteinsPrrx1 protein, mouseStat3 protein, mouseSTAT3 Transcription FactorJob's syndromeperiodontal ligament (PDL)root developmentsignal transducer and activator of transcription 3

Identifiers

PMID40938212
PMCPMC12712749

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.