Evidence map›Paper›PMID 40938195›Full record

ArticleACS applied bio materials2025

Dual Action Nitric Oxide-Releasing Polydimethylsiloxane Sponge: Preventing Infection in Needleless Connectors.

Adam Brooks Goodman, Manjyot Kaur Chug, Natalie Crutchfield, Mark Garren, Hitesh Handa, Elizabeth J Brisbois

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Adam Brooks GoodmanSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.ORCID 0009-0001-7594-8387
Manjyot Kaur ChugSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0001-8194-4481
Natalie CrutchfieldSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.
Mark GarrenSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0001-5194-6558
Hitesh HandaSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0002-9369-7374
Elizabeth J BrisboisSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0002-9283-5448

Funding

Bioinspired antifouling and thromboresistant polymers for blood-contacting interfacesR01HL151473 · NHLBI · UNIVERSITY OF GEORGIA · PI BRISBOIS, ELIZABETH JOY · 2020 to 2023
$1.4M
NHLBI NIH HHS R01 HL151473
6 · The paper itself

Abstract

Catheter-related bloodstream infections (CRBSIs) are a prevalent concern, often resulting from suboptimal disinfection practices of needleless connectors. Although alcohol-based disinfectants have demonstrated efficacy, there is growing concern about developing microbial resistance. Similar to antibiotics in recent decades, microbes have the potential to develop resistance to these alcohol-based therapies. Therefore, this study delves into the antimicrobial potential of nitric oxide (NO), an endogenous gas molecule with broad-spectrum antimicrobial properties, in combination with the widely used disinfectant 70% isopropanol (IPA). Due to its short half-life, NO presents minimal risk of microbial resistance development. By incorporating

Indexed as

Anti-Bacterial AgentsBiocompatible MaterialsCatheter-Related InfectionsDimethylpolysiloxanesNitric OxideEscherichia coliMaterials TestingMicrobial Sensitivity TestsParticle SizeS-Nitroso-N-AcetylpenicillamineStaphylococcus aureusSurface PropertiesAnti-Bacterial AgentsbaysilonBiocompatible MaterialsDimethylpolysiloxanesNitric OxideS-Nitroso-N-Acetylpenicillamineantimicrobialdisinfecting capsisopropanolnitric oxidepolydimethylsiloxane sponge

Identifiers

PMID40938195
PMCPMC12541702

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.