ArticleRadiology. Imaging cancer2025
High-Resolution Mapping of Tumor and Peritumoral Glutamate and Glutamine in Gliomas Using 7-T MRSI.
Article in Radiology. Imaging cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Predictions and cross-center validation of IDH status and 1p/19q status in adult diffuse glioma with non-invasive magnetic resonance spectroscopy.Magnetic resonance letters · 2027Article
- Ultra-high-field 7-Tesla MRI in neuro-oncology: a narrative review of current applications and future directions.Quantitative imaging in medicine and surgery · 2026Review
- Absolute Quantification of Brain Deuterium Metabolic Imaging in Healthy Volunteers and Glioblastoma Patients at 7T.Magnetic resonance in medicine · 2026Article
- Epilepsy: Bridging Epidemiological Landscapes, Molecular Mechanisms, and Emerging Precision Therapeutics.Neuropsychiatric disease and treatment · 2026Review
- 7-T MRSI Mapping of Glutamate and Glutamine in Diffuse Gliomas.Radiology. Imaging cancer · 2025Article
- Glutamine Metabolism and Metabolic Profiling Using 7 T CRT-FID MRSI in Focal Epilepsy.European journal of neurology · 2025Article
- Optimized Long-TEJournal of magnetic resonance imaging : JMRI · 2025Article
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16 authors.
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Abstract
Purpose To evaluate glutamate (Glu) and glutamine (Gln) concentrations in patients with glioma using 7-T MR spectroscopic imaging, identify significant differences in metabolic ratios between tumor and peritumoral regions, and assess associations of Glu and Gln with tumor-associated epilepsy and other tumor characteristics. Materials and Methods This retrospective study included data from patients with gliomas who underwent 7-T MR spectroscopic imaging in a single university hospital between September 2018 and April 2021. Median values for nine metabolic ratios were calculated within the visible tumor and peritumoral shell, and Dice similarity coefficients were used to assess the spatial overlap of elevated metabolic regions between these compartments. Statistical significance between regions of interest and between glioma attributes (eg, isocitrate dehydrogenase status) was assessed. Results Thirty-six patients (median age, 52 years [IQR, 23 years]; 22 male, 14 female) were included in the study. The Glu to total creatine (Glu/tCr) median was significantly higher in the peritumoral volume of interest (median, 1.13) compared with the tumor (median, 0.92;
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