Evidence map›Paper›PMID 40938089›Full record

ArticleThe American journal of sports medicine2025

Measures of Patellofemoral Morphology Predict the Risk of Local Cartilage Damage Progression: A Yale/MOST Collaborative Study.

Nancy Park, Johannes M Sieberer, Brooke McGinley, Armita R Manafzadeh, John Lynch, Neil A Segal, Cora E Lewis, Ali Guermazi, Frank W Roemer, Joshua Stefanik and 2 more

Registry-linked trialAbstract readMulticenter Study
In one paragraph

Article in The American journal of sports medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07472088 (Assessing the Association Between WBCT PFJ Morphological Metrics and Knee Symptoms), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07472088 recruitingnot on this mapstarted 2026, after this paper: background citation

Assessing the Association Between WBCT PFJ Morphological Metrics and Knee Symptoms

TypeobservationalSponsorUniversity of Kansas Medical CenterRan2026 to 2026Enrolled36ConditionsKnee Osteoarthritis, Patellofemoral Pain (PFPS)ArmsWBCT
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nancy ParkDepartment of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-7643-1507
Johannes M SiebererDepartment of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-4191-3442
Brooke McGinleyDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Armita R ManafzadehInstitute for Biospheric Studies, Yale University, New Haven, Connecticut, USA.ORCID 0000-0001-5388-7942
John LynchDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Neil A SegalDepartment of Physical Medicine and Rehabilitation, University of Kansas Medical Center, Kansas City, Kansas, USA.
Cora E LewisDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Ali GuermaziDepartment of Radiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Frank W RoemerDepartment of Radiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Joshua StefanikNortheastern University, Boston, Massachusetts, USA.
David T FelsonSection of Rheumatology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
John P FulkersonDepartment of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, Connecticut, USA.

Funding

Project 3: Intraarticular MineralizationU19AG076471 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DAVID Tobin FELSON · 2023 to 2026
$49.0M
Multicenter Osteoarthritis Study (MOST) Second RenewalU01AG019069 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEVITT, MICHAEL C · 2001 to 2020
$21.7M
Multicenter Osteoarthritis Study (MOST) Second Renewal: Iowa Clinical CenterU01AG018832 · NIA · UNIVERSITY OF IOWA · PI SEGAL, NEIL A, TORNER, JAMES C · 2001 to 2020
$14.1M
Multicenter Osteoarthritis Study (MOST) Second Renewal - Boston UniversityU01AG018820 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FELSON, DAVID TOBIN · 2001 to 2019
$13.6M
Multicenter Osteoarthritis Study (MOST) Second Renewal - UAB Clinical CenterU01AG018947 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA E · 2001 to 2020
$13.2M
Research and Evaluation Support Core Unit (RESCU Core)P30AR072571 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2019 to 2026
$6.9M
BUSPH Interdisciplinary Training Program for BiostatisticiansT32GM140972 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Kathryn L Lunetta, Laura Forsberg White · 2021 to 2026
$1.9M
NIAMS NIH HHS P30 AR072571NIA NIH HHS U01 AG018820NIA NIH HHS U01 AG018832NIA NIH HHS U01 AG018947NIA NIH HHS U01 AG019069NIA NIH HHS U19 AG076471NIGMS NIH HHS T32 GM140972
6 · The paper itself

Abstract

backgroundThe relationship between patellofemoral (PF) morphology and PF cartilage damage in the general population remains unclear. PURPOSE: This study aimed to determine whether 3-dimensional-based metrics of PF morphology are associated with progressive lateral PF cartilage damage. STUDY

designCross-sectional study; Level of evidence, 2.

methodsWe analyzed nonweightbearing computed tomography scans of knees from a subset of participants enrolled in the community-based Multicenter Osteoarthritis Study. Baseline and 2-year magnetic resonance imaging scans of the knee were evaluated for progressive PF cartilage damage using the Magnetic Resonance Imaging Osteoarthritis Knee Score. Tibial tubercle-trochlear groove (TT-TG) distance, patellar tilt, external tibiofemoral rotation (eTFR), patellar height, entry point-trochlear groove angle, and entry point-transition point (EP-TP) angle were measured for each knee. To assess the association of each morphology measure with progressive cartilage damage, logistic regression models with generalized estimating equations were fit using continuous and natural cubic spline models.

resultsWe analyzed lateral PF cartilage damage in 389 knees (mean age, 53.79 ± 5.51 years; mean body mass index, 28.48 ± 5.13 kg/m

conclusionThe results demonstrated significant associations between 3-dimensional anatomic metrics and progressive lateral PF cartilage damage. Elevated TT-TG distance, eTFR, and EP-TP angle may be keys to understanding the mechanical cause of lateral PF osteoarthritis.

Indexed as

Cartilage, ArticularOsteoarthritis, KneePatellaPatellofemoral JointAdultCross-Sectional StudiesDisease ProgressionFemaleHumansImaging, Three-DimensionalMagnetic Resonance ImagingMaleMiddle AgedTomography, X-Ray Computedcartilage prognosisosteoarthritispatellofemoral diseasepatellofemoral morphology

Identifiers

PMID40938089
PMCPMC12435904

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.