Trial reportTransfusion2025
SARS-CoV-2 convalescent plasma for the controlled clinical trial "COVIC-19": Experience from collection of very high-titer plasma from superimmunized individuals.
Trial report in Transfusion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05271929 (A Randomised Open-Label Trial of Early, Very High-Titre Convalescent Plasma Therapy in Clinically Vulnerable Individuals With Mild COVID-19), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomised Open-Label Trial of Early, Very High-Titre Convalescent Plasma Therapy in Clinically Vulnerable Individuals With Mild COVID-19
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
backgroundCOVID-19 convalescent plasma (CCP) is a treatment option for COVID-19. Understanding of donor and product characteristics is important for optimization of CCP therapy. We report the experience of collection of very high-titer CCP for the trial "A randomized open-label trial of early, very high-titer convalescent plasma therapy in clinically vulnerable individuals with mild COVID-19" (COVIC-19) (NCT05271929). STUDY DESIGN AND
methodsIndividuals who had recovered from COVID-19 and had ≥1 dose of a SARS-CoV-2 vaccine were recruited as donors for CCP. Anti-SARS-CoV-2 antibodies were measured by ELISA, and neutralization capacity against SARS-CoV-2 variants was assessed in surrogate and pseudovirus-neutralization assays. Correlation of antibody titers with donor characteristics and antibody kinetics was analyzed.
resultsWe recruited 688 potential donors. 41.4% of individuals had antibody concentrations of ≥4000 BAU/ml (anti-SARS-CoV-2 IgG ELISA [QuantiVac]). Concentrations did not significantly differ by sex or ABO type, but were higher among those who had received at least three vaccinations. Highest titers were observed in those with a breakthrough infection after two vaccinations, followed by a booster (median 5374 BAU/mL) or breakthrough infection after the 3rd or 4th vaccination (median 3846 BAU/mL). Ultimately, 172 eligible individuals donated CCP with a median concentration of 6858 BAU/mL (range 4015-22,923 BAU/mL). DISCUSSION: We demonstrate the feasibility of the collection of very high-titer CCP products under a harmonized protocol for a randomized clinical trial, but it requires substantial donor selection, appropriate antibody assays, rapid succession of screening, and apheresis to take advantage of the short period of very high antibody concentrations.
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