Evidence map›Paper›PMID 40937888›Full record

ArticleJournal of diabetes investigation2025

Associations between peripheral blood mitochondrial genomic variants and gestational diabetes mellitus and postpartum abnormal glucose metabolism.

Qing Luo, Jiankun Zhou, Haiyun Wu, Xiayan Qiu, Chunyan Xian, Xiaoting Zhan, Jinbo Liu

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In one paragraph

Article in Journal of diabetes investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Qing Luo *Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Sichuan Province Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases, Molecular Diagnosis of Clinical Diseases Key Laboratory of Luzhou, Luzhou, Sichuan, China.ORCID https://orcid.org/0000-0003-2596-8862
Jiankun Zhou *Department of Medical Laboratory, Southwest Medical University, Luzhou, Sichuan, China.
Haiyun WuDepartment of Medical Laboratory, Southwest Medical University, Luzhou, Sichuan, China.
Xiayan QiuDepartment of Medical Laboratory, Southwest Medical University, Luzhou, Sichuan, China.
Chunyan XianDepartment of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Sichuan Province Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases, Molecular Diagnosis of Clinical Diseases Key Laboratory of Luzhou, Luzhou, Sichuan, China.
Xiaoting ZhanDepartment of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Sichuan Province Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases, Molecular Diagnosis of Clinical Diseases Key Laboratory of Luzhou, Luzhou, Sichuan, China.
Jinbo LiuDepartment of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Sichuan Province Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases, Molecular Diagnosis of Clinical Diseases Key Laboratory of Luzhou, Luzhou, Sichuan, China.

Funding

Luzhou Science and Technology Bureau 2023JYJ052Sichuan Province College Students Innovation and Entrepreneurship Training Program S202310632167Southwest Medical University 2021ZKQN060
6 · The paper itself

Abstract

AIMS/

introductionThe aim of the study was to investigate the association of single nucleotide polymorphisms, haplogroups, and copy number in the D-loop region of mitochondrial DNA (mtDNA) with the genetic susceptibility to gestational diabetes mellitus (GDM) and postpartum abnormal glucose metabolism (AGM). MATERIALS AND

methodsThis was a case-control study in which peripheral blood samples were collected from 500 GDM patients and 500 normal pregnant women from 14 to 20 weeks of pregnancy. The sequence of the D-loop region of mtDNA was detected by Sanger sequencing, and the copy number of mtDNA was detected by qPCR.

resultsAnalysis of SNPs in the D-loop region of mtDNA showed that 249d was a risk factor and 309+C and 16193+C were protective factors for GDM. The mtDNA haplogroups R9 and M* were a risk factor and protective factor for GDM, respectively. Compared to the group with normal postpartum glucose tolerance, the haplogroups M7b and N9a were associated with an increased risk of AGM. The whole blood mtDNA copy number was lower in the GDM group than in the control group and was also lower in the postpartum AGM group than in the postpartum normal group. The plasma free mtDNA copy number was higher in the GDM group than in the control group, and higher in the postpartum AGM group than in the normal postpartum group.

conclusionsMitochondrial genomic variants are associated with the risk of GDM and postpartum AGM, and may provide some etiologic evidence for GDM and postpartum AGM.

Indexed as

Diabetes, GestationalDNA, MitochondrialGenome, MitochondrialGlucose Metabolism DisordersPolymorphism, Single NucleotidePostpartum PeriodAdultBlood GlucoseCase-Control StudiesDNA Copy Number VariationsFemaleGenetic Predisposition to DiseaseHaplotypesHumansPregnancyPrognosisBlood GlucoseDNA, MitochondrialGestational diabetes mellitusMitochondrial DNA copy numberMitochondrial DNA haplogroup

Identifiers

PMID40937888
PMCPMC12578659

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