Evidence map›Paper›PMID 40937881›Full record

ArticleAdvanced biology2025

RRP9 Promotes Esophageal Squamous Cell Carcinoma Progression through E2F1 Transcriptional Regulation of CDK1.

Gang He, Yilong Wan, Yanbo Zhu, Bo Peng, Shengxiang Shao, Xinyi Zou, Zhenyu Han, Jiaxi Li, Sheng Ju, Xin Tong and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gang HeDepartment of Thoracic Surgery, Fengxian District Central Hospital, Shanghai, 385686, China.
Yilong WanDepartment of Thoracic Surgery, Institute of Thoracic Surgery, The First Affiliated Hospital of Soochow University, No.899 Pinghai Road, Suzhou, Jiangsu, 215005, China.
Yanbo ZhuOncology department, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 74565, China.
Bo PengThoracic and Cardiothoracic Surgery Department, Suzhou Ninth People's Hospital, Suzhou, Jiangsu, 604074, China.
Shengxiang ShaoMedical College of Soochow University, Suzhou, Jiangsu, 74565, China.
Xinyi ZouDepartment of Thoracic Surgery, Institute of Thoracic Surgery, The First Affiliated Hospital of Soochow University, No.899 Pinghai Road, Suzhou, Jiangsu, 215005, China.
Zhenyu HanDepartment of Thoracic Surgery, Institute of Thoracic Surgery, The First Affiliated Hospital of Soochow University, No.899 Pinghai Road, Suzhou, Jiangsu, 215005, China.
Jiaxi LiDepartment of Thoracic Surgery, Institute of Thoracic Surgery, The First Affiliated Hospital of Soochow University, No.899 Pinghai Road, Suzhou, Jiangsu, 215005, China.
Sheng JuDepartment of Thoracic Surgery, Institute of Thoracic Surgery, The First Affiliated Hospital of Soochow University, No.899 Pinghai Road, Suzhou, Jiangsu, 215005, China.
Xin TongDepartment of Thoracic Surgery, Institute of Thoracic Surgery, The First Affiliated Hospital of Soochow University, No.899 Pinghai Road, Suzhou, Jiangsu, 215005, China.
Jun ZhaoDepartment of Thoracic Surgery, Institute of Thoracic Surgery, The First Affiliated Hospital of Soochow University, No.899 Pinghai Road, Suzhou, Jiangsu, 215005, China.
Hansi LiangJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215005, China.
Liuqing ZhangMedical College of Soochow University, Suzhou, Jiangsu, 74565, China.
Jiashi XiongDepartment of Thoracic Surgery, Fengxian District Central Hospital, Shanghai, 385686, China.ORCID 0009-0005-7341-3580
Dong JiangDepartment of Thoracic Surgery, Institute of Thoracic Surgery, The First Affiliated Hospital of Soochow University, No.899 Pinghai Road, Suzhou, Jiangsu, 215005, China.ORCID 0000-0002-6779-6192

Funding

Boxi Culture Project of First Affiliated Hospital of Soochow University BXQN202120National Natural Science Foundation of China 81972800National Natural Science Foundation of China 82203276Shanghai Fengxian District (social) science and technology development project 20201406Shanghai Fengxian District (social) science and technology development project 20201411State key laboratory open project GZK1202226State key laboratory open project GZK12023036Suzhou Health Talent Training Project GSWS2020008Suzhou new Diagnosis and Treatment Technology Research SKY2023044
6 · The paper itself

Abstract

Esophageal cancer is a major disease that seriously threatens human health. Ribosomal RNA biogenesis is implicated in tumorigenesis, while the small nucleolar RNAs (snoRNAs) are responsible for post-transcriptional modifications of ribosomal RNAs during biogenesis, which are identified as potential markers of various cancers. The clinical significance, biological behavior, and potential molecular mechanism of the nucleolar small nuclear ribonucleoprotein RRP9 in esophageal squamous cell carcinoma (ESCC), which is a major pathological type of esophageal cancer, are investigated in this study. It is found that RRP9 is abnormally highly expressed in ESCC tissues and is closely associated with poor prognosis. Furthermore, it is found that RRP9 could regulate the cell cycle protein-dependent kinase CDK1 to promote ESCC progression in vitro and in vivo. Mechanistically, RRP9 promotes ESCC progression through enhancing the E2F1-mediated transcriptional regulation of CDK1. Collectively, the results defined RRP9 as an important tumor driver in ESCC that acted by activating oncogenic signaling by the E2F1-CDK1 pathway, and suggested RRP9 as a candidate therapeutic target for ESCC.

Indexed as

CDC2 Protein KinaseE2F1 Transcription FactorEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaRibonucleoproteinsAnimalsCell Line, TumorCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMaleMiceMice, Inbred BALB CMice, NudeCDC2 Protein KinaseCDK1 protein, humanE2F1 protein, humanE2F1 Transcription FactorRibonucleoproteinsCDK1E2F1esophageal squamous cell carcinoma (ESCC)RRP9transcriptional regulation

Identifiers

PMID40937881
PMCPMC12712745

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.