ArticleClinical and translational allergy2025
Persistent Off-Season Dysregulation of Memory B Cell Subsets in Allergic Rhinitis.
Article in Clinical and translational allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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7 authors.
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Abstract
introductionAllergic rhinitis (AR) is a common allergic airway disease. Although B cells play essential roles in AR pathogenesis, their subset distribution outside the allergen exposure period remains poorly characterized.
objectiveTo profile peripheral blood B cell subsets in AR patients during the pollen-free season and compare them with healthy controls (HC), aiming to identify persistent immunological alterations and potential biomarkers.
methodsPeripheral blood mononuclear cells (PBMCs) were collected from a total of 28 participants, 14 patients with allergic rhinitis (AR) and 14 healthy controls (HC) during the off-season. B cell subsets were identified using flow cytometry based on IgD and CD27 expression, classifying cells as naïve (IgD
resultsAR patients displayed lower frequencies of IgG1
conclusionEven outside allergen exposure, AR patients exhibit systemic B cell dysregulation, characterized by skewed class switching, altered subset distribution, and reduced activation markers expression. These findings underscore persistent immune imbalance in AR, identify potential off-season biomarkers of allergic inflammation.
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