Evidence map›Paper›PMID 40937851›Full record

ArticlemBio2025

Fungal mitochondria govern both gliotoxin biosynthesis and self-protection.

Patrícia Alves de Castro, Endrews Delbaje, Ivan Lucas de Freitas Migliorini, Monica T Pupo, Muhammad Shafiul Alam Mondal, Karin Steffen, Antonis Rokas, Stephen K Dolan, Gustavo H Goldman

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Patrícia Alves de CastroFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.ORCID 0000-0003-3045-6511
Endrews DelbajeFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Ivan Lucas de Freitas MiglioriniFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Monica T PupoFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.ORCID 0000-0003-2705-0123
Muhammad Shafiul Alam MondalDepartment of Genetics and Biochemistry, Eukaryotic Pathogens Innovation Center, Clemson University, Clemson, South Carolina, USA.
Karin SteffenDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA.
Antonis RokasDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0002-7248-6551
Stephen K DolanDepartment of Genetics and Biochemistry, Eukaryotic Pathogens Innovation Center, Clemson University, Clemson, South Carolina, USA.ORCID 0000-0002-7391-2137
Gustavo H GoldmanFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.ORCID 0000-0002-2986-350X

Funding

Regulation of Cryptosporidium DevelopmentP20GM146584 · NIGMS · CLEMSON UNIVERSITY · PI Christopher Donald Chouinard · 2022 to 2026
$13.5M
Deciphering the phenotypic and genomic traits that underlie the evolution of pathogenicity differences among Aspergillus fumigatus and its close relativesR01AI153356 · NIAID · VANDERBILT UNIVERSITY · PI Antonis Rokas · 2022 to 2026
$3.5M
Defining mechanisms of fungal-bacterial interactions during infectionK22AI174009 · NIAID · CLEMSON UNIVERSITY · PI DOLAN, STEPHEN K · 2024 to 2025
$250k
Fundação de Amparo à Pesquisa do Estado de São PauloNIAID NIH HHS K22 AI174009NIAID NIH HHS R01 AI153356NIGMS NIH HHS P20 GM146584
6 · The paper itself

Abstract

Gliotoxin (GT) is a potent epipolythiodioxopiperazine toxin produced by the opportunistic pathogen

Indexed as

Aspergillus fumigatusAspergillus nidulansGliotoxinMitochondriaFungal ProteinsGene DeletionGene Expression ProfilingGene Expression Regulation, FungalOxidative StressTranscription FactorsFungal ProteinsGliotoxinTranscription FactorsAspergillus fumigatusgliotoxintranscriptional profilingubiquinone

Identifiers

PMID40937851
PMCPMC12505978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.