Evidence map›Paper›PMID 40937850›Full record

ArticlemBio2025

PRRSV promotes bacterial infection by remodeling actin cytoskeleton and cell membrane proteins.

Xiao Liu, Fang Lv, Yanan Zhu, Yinan Meng, Bo Peng, Zifang Zheng, Yang Li, Lele Xu, Yingtong Feng, Jianwu Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiao Liu *State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.ORCID 0000-0003-0038-5046
Fang Lv *College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
Yanan ZhuCollege of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
Yinan MengCollege of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
Bo PengCollege of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
Zifang ZhengState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
Yang LiState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
Lele XuState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
Yingtong FengState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
Jianwu ZhangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
Shuqi XiaoState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.ORCID 0000-0002-6468-2608

Funding

Basic Research Center, Innovation Program of Chinese Academy of Agricultural Sciences CAAS-BRC-LPDC-2025-02Joint Research Foundation of Gansu Province 23JRRA1476Joint Research Foundation of Gansu Province 23JRRA1480Major Scientific and Technological Special Project of Gansu Province 22ZD6NA001Major Scientific and Technological Special Project of Gansu Province 23ZDNA007Major Scientific and Technological Special Project of Gansu Province 24ZD13NA008National Key Research and Development Program of China 2022YFD1800304National Natural Science Foundation of China 32172846National Natural Science Foundation of China 32430106SKLADCP SKLADCP2025HP03
6 · The paper itself

Abstract

Secondary infection is a worldwide problem in the prevention and control of viral infection. Secondary bacterial infection induced by porcine reproductive and respiratory syndrome virus (PRRSV) infection causes enormous economic losses, but the relevant mechanism remains unclear. We found that the infection of IMPORTANCE: An important reason why porcine reproductive and respiratory syndrome virus (PRRSV) is difficult to control effectively is that it often causes severe secondary bacterial infections, which are usually attributed to the immunosuppression caused by PRRSV. However, the mechanism by which PRRSV infection leads to increased susceptibility of cells to bacterial infection has been largely overlooked. We revealed that PRRSV induced actin cytoskeleton rearrangement by upregulating FLNA expression, thereby aggravating bacterial invasion. PRRSV increased bacterial adhesion by promoting the ITGα5 expression, and the upregulation of ITGα5 could induce FLNA-mediated actin cytoskeleton rearrangement. Furthermore, we found that H1N1 and porcine circovirus type 2 infection also significantly promoted the expression of FLNA and ITGα5 and increased the infection of multiple bacteria. These results suggest that FLNA and ITGα5 play important roles in virus-induced secondary bacterial infection.

Indexed as

Actin CytoskeletonCoinfectionMembrane ProteinsPorcine Reproductive and Respiratory SyndromePorcine respiratory and reproductive syndrome virusAnimalsBacterial AdhesionFilaminsKlebsiella InfectionsLungMiceStreptococcus suisSwineFilaminsMembrane Proteinsactin cytoskeletonFLNAITGα5PRRSVsecondary bacterial infection

Identifiers

PMID40937850
PMCPMC12506063

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.