Evidence map›Paper›PMID 40937825›Full record

ArticleEpilepsia open2025

Potential of

Denis Schwartz, Jean-Michel Badier, Tjerk P Gutteling, Sébastien Daligault, Etienne Labyt, Francesca Bonini, Julien Jung

Abstract readComparative Study
In one paragraph

Article in Epilepsia open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Potential ofEpilepsia open · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Denis SchwartzMEG Department, CERMEP-Imagerie du Vivant, Lyon, France.ORCID https://orcid.org/0000-0002-8557-2934
Jean-Michel BadierINSERM, INS, Inst Neurosci Syst, Aix Marseille Univ, Marseille, France.
Tjerk P GuttelingMEG Department, CERMEP-Imagerie du Vivant, Lyon, France.
Sébastien DaligaultMEG Department, CERMEP-Imagerie du Vivant, Lyon, France.
Etienne LabytMAG4Health, Grenoble, France.
Francesca BoniniINSERM, INS, Inst Neurosci Syst, Aix Marseille Univ, Marseille, France.
Julien JungCRNL, UMR_S 1028, INSERM, CNRS, Lyon University 1, HCL, Lyon, France.ORCID https://orcid.org/0000-0002-9274-0086

Funding

Agence Nationale de la Recherche ANR-11-INBS-0006Agence Nationale de la Recherche ANR-16-CONV-0002Agence Nationale de la Recherche ANR-22-CE19-0012-01Excellence Initiative of Aix-Marseille University - A*MIDEX AMX-19-IET-002Labex Cortex ANR-11-LABX-0042Région Auvergne-Rhône-Alpes
6 · The paper itself

Abstract

objectivesConventional magnetoencephalography (MEG) based on superconducting quantum interference devices sensors (SQUIDs) is the only widely used MEG system in both clinical and research settings. However, it has limitations that hinder its widespread deployment. Optically pumped magnetometers (OPMs) offer several advantages over SQUIDs, particularly for epilepsy studies: lightweight and flexible, OPMs can be integrated into adaptable motion-tolerant headsets, enabling recordings during seizures or natural head movements, and potentially enhancing the detection of interictal epileptiform discharges (IEDs). In the present study, we assess the capabilities of a 5-sensor MEG system with helium OPMs (

methodsFirst, we compare the performance of SQUID-MEG and

resultsThe key finding is that both the SQUID-MEG and the SIGNIFICANCE: These results strongly support the clinical adoption of a lightweight, high-sensitivity, whole-head OPMs-MEG system, offering new perspectives for epilepsy diagnostics and beyond, and enabling the democratization and spread of MEG in clinical and research settings. PLAIN LANGUAGE SUMMARY: Magnetoencephalography is a noninvasive neuroimaging technique that has been shown to improve surgical outcomes in epileptic patients. However, its use remains limited due to several constraints, which could be overcome by a new generation of sensors: the optically pumped magnetometers (OPMs). Here, we validate the ability of OPM sensors to record epileptic brain activity in a regular clinical setup and thanks to simultaneous intracerebral recordings. These sensors open new venues for the widespread application of magnetoencephalography in the management of epilepsy, as well as for fundamental neuroscience.

Indexed as

EpilepsyHeliumMagnetoencephalographyAdultBrainElectroencephalographyFemaleHumansMaleMiddle AgedYoung AdultHeliumepilepsyinterictal epileptic dischargesmagnetoencephalographyoptically pumped magnetometerssimultaneous recordingstereotactic‐EEG

Identifiers

PMID40937825
PMCPMC12514395

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.