Evidence map›Paper›PMID 40937764›Full record

ArticleMicrobiology spectrum2025

Functional characterization and membrane localization of the styrene oxide isomerase from

Selvapravin Kumaran, Shanice Olanipekun, Latife Sönmez, Lars Janzen, Peter-Leon Hagedoorn, Dirk Tischler

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Selvapravin KumaranMicrobial Biotechnology, Ruhr University Bochum, Bochum, Germany.ORCID 0000-0002-0799-9211
Shanice Olanipekun *Microbial Biotechnology, Ruhr University Bochum, Bochum, Germany.
Latife Sönmez *Microbial Biotechnology, Ruhr University Bochum, Bochum, Germany.
Lars JanzenMicrobial Biotechnology, Ruhr University Bochum, Bochum, Germany.
Peter-Leon HagedoornDepartment of Biotechnology, Delft University of Technology, Delft, the Netherlands.ORCID 0000-0001-6342-2022
Dirk TischlerMicrobial Biotechnology, Ruhr University Bochum, Bochum, Germany.ORCID 0000-0002-6288-2403

Funding

Deutsche Bundesstiftung Umwelt 20007/939European Social Fund 100101363
6 · The paper itself

Abstract

Styrene oxide isomerase (SOI) is a part of the styrene degradation enzyme complex, performing the isomerization of toxic intermediate styrene oxide into phenylacetaldehyde. For many years, the enzyme was believed to be cofactor-independent, and hence, the mechanism of this enzyme was proposed to be acid-base catalysis. Recently, the presence of heme was identified and reported in SOI from IMPORTANCE: Styrene oxide isomerase (SOI) catalyzes the isomerization of styrene oxide into phenylacetaldehyde in the side chain oxygenation of the styrene degradation pathway. Despite performing a key role in this pathway, the biology and biochemistry of this enzyme are poorly understood, particularly its catalytic mechanism, membrane localization, and structure-function relationships. SOIs from

Indexed as

Bacterial ProteinsCell MembraneEpoxy CompoundsIsomerasesRhodococcusEscherichia coliHemeMutagenesis, Site-DirectedStyreneBacterial ProteinsEpoxy CompoundsHemeIsomerasesStyrenestyrene oxidecytosolic terminiEPRfluorescence microscopyIntegral membrane proteinmembrane anchorsfGFP/SUMOsite-directed mutagenesisterminal extensiontruncation

Identifiers

PMID40937764
PMCPMC12502698

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.