Evidence map›Paper›PMID 40937720›Full record

ArticleGut microbes2025

Live biotherapeutic

Yibo Xian, Zhipeng Chen, Zhou Lan, Chenchen Zhang, Hao Sun, Zhenzhen Liu, Ping Kong, Yajun Liang, Yingying Zhao, Si-Yang Maggie Liu and 12 more

Abstract read
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Frontiers in immunology · 2026
    Review
  6. Review
  7. Frontiers in nutrition · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Yibo XianMoon (Guangzhou) Biotech Co. Ltd, Guangdong, China.
Zhipeng ChenMoon (Guangzhou) Biotech Co. Ltd, Guangdong, China.
Zhou LanMoon (Guangzhou) Biotech Co. Ltd, Guangdong, China.
Chenchen ZhangMoon (Guangzhou) Biotech Co. Ltd, Guangdong, China.
Hao SunGuangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Zhenzhen LiuMoon (Guangzhou) Biotech Co. Ltd, Guangdong, China.
Ping KongMoon (Guangzhou) Biotech Co. Ltd, Guangdong, China.ORCID 0009-0004-1102-8663
Yajun LiangMoon (Guangzhou) Biotech Co. Ltd, Guangdong, China.
Yingying ZhaoMoon (Guangzhou) Biotech Co. Ltd, Guangdong, China.
Si-Yang Maggie LiuGuangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Yiqi ZhouMoon (Guangzhou) Biotech Co. Ltd, Guangdong, China.
Linchuan GanMoon (Guangzhou) Biotech Co. Ltd, Guangdong, China.
Baoxia LiMoon (Guangzhou) Biotech Co. Ltd, Guangdong, China.
Xue SuMoon (Guangzhou) Biotech Co. Ltd, Guangdong, China.
Baojia HuangMoon (Guangzhou) Biotech Co. Ltd, Guangdong, China.
Chen XiaoMoon (Guangzhou) Biotech Co. Ltd, Guangdong, China.
Ruijuan ZhuMoon (Guangzhou) Biotech Co. Ltd, Guangdong, China.
Guozhen ZhaoMoon (Guangzhou) Biotech Co. Ltd, Guangdong, China.
Canshan LaoMoon (Guangzhou) Biotech Co. Ltd, Guangdong, China.
Chuan-Sheng LinMoon (Guangzhou) Biotech Co. Ltd, Guangdong, China.
Dongya ZhangMoon (Guangzhou) Biotech Co. Ltd, Guangdong, China.
Xianzhi JiangMoon (Guangzhou) Biotech Co. Ltd, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiome has the potential to influence tumor development and affect the efficacy of cancer therapeutics, particularly immunotherapy. However, the specific species and strains rather than all microbes that promote antitumor immunity by modulating the function of systemic immunity or tumor-infiltrating lymphocytes (TILs) in tumor environments remain to be elucidated. In this study, we analyzed the microbiome composition of responders and non-responders to PD-1 blockade therapy from a clinical cohort and found that

Indexed as

EnterococcusImmune Checkpoint InhibitorsMembrane ProteinsNeoplasmsProbioticsAnimalsCell Line, TumorFemaleGastrointestinal MicrobiomeHumansImmunity, InnateImmunotherapyMaleMiceMice, Inbred C57BLSignal TransductionImmune Checkpoint InhibitorsMembrane ProteinsSTING1 protein, humanSTING Proteinbacterial membrane vesiclesEnterococcus lactisimmune systemimmunotherapyMNC-168STING

Identifiers

PMID40937720
PMCPMC12439585

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.