Evidence map›Paper›PMID 40937719›Full record

ArticleeLife2025

Tuberculosis susceptibility in genetically diverse mice reveals functional diversity of neutrophils.

Marietta M Ravesloot-Chavez, Erik Van Dis, Douglas Fox, Andrea Anaya-Sanchez, Scott Espich, Xammy Huu Nguyenla, Sagar Rawal, Helia Samani, Mallory Ballinger, Henry F Thomas and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Marietta M Ravesloot-ChavezDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, United States.ORCID https://orcid.org/0000-0001-5129-7156
Erik Van DisDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.
Douglas FoxDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.
Andrea Anaya-SanchezDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, United States.
Scott EspichSchool of Public Health, Division of Infectious Disease and Vaccinology, University of California, Berkeley, Berkeley, United States.
Xammy Huu NguyenlaDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID https://orcid.org/0000-0002-7532-8356
Sagar RawalDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.
Helia SamaniDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.
Mallory BallingerDepartment of Integrative Biology, University of California, Berkeley, Berkeley, United States.
Henry F ThomasDepartment of Integrative Biology, University of California, Berkeley, Berkeley, United States.
Dmitri I KotovDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID https://orcid.org/0000-0001-7843-1503
Russell E VanceDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID https://orcid.org/0000-0002-6686-3912
Michael W NachmanDepartment of Integrative Biology, University of California, Berkeley, Berkeley, United States.
Sarah A StanleyDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID https://orcid.org/0000-0002-4182-9048

Funding

The role of Listeria cyclic-di-AMP during infection and immunityP01AI063302 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI PORTNOY, DANIEL A · 2004 to 2025
$45.5M
Metabolic regulation of macrophage function during M. tuberculosis infectionR01AI113270 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI STANLEY, SARAH A · 2015 to 2024
$3.8M
Natural selection and DNA sequence variation in MusR01GM074245 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI NACHMAN, MICHAEL W. · 2005 to 2015
$3.0M
The genomic basis of environmental adaptation in miceR01GM127468 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI NACHMAN, MICHAEL W. · 2018 to 2021
$1.3M
Modeling tuberculosis infection in a new collection of genetically diverse miceR21AI146810 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI STANLEY, SARAH A · 2019 to 2020
$432k
National Institute of Allergy and Infectious Diseases R21AI146810National Science Foundation GRFPNIAID NIH HHS P01 AI063302NIAID NIH HHS R01 AI113270NIAID NIH HHS R21 AI146810NIGMS NIH HHS GM127468NIGMS NIH HHS R01 GM074245NIGMS NIH HHS R01 GM127468
6 · The paper itself

Abstract

Tuberculosis is a heterogeneous disease in humans with individuals exhibiting a wide range of susceptibility. This heterogeneity is not captured by standard laboratory mouse lines. We used a new collection of 19 wild-derived inbred mouse lines collected from diverse geographic sites to identify novel phenotypes during

Indexed as

Genetic Predisposition to DiseaseMycobacterium tuberculosisNeutrophilsTuberculosisAnimalsDisease Models, AnimalDisease SusceptibilityFemaleLungMaleMiceMice, Inbred C57BLinfectious diseasemicrobiologymouseMycobacterium tuberculosisneutrophilswild-derived mice

Identifiers

PMID40937719
PMCPMC12431774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.