Evidence map›Paper›PMID 40937639›Full record

ArticleCancer medicine2025

Associations of the Colon Tissue Microbiome and Circulating Bile Acids With Colorectal Adenoma Among Average-Risk Women.

Doratha A Byrd, Maria F Gomez, Stephanie R Hogue, Jessica R Burns, Nate Smith, Joshua Sampson, Erikka Loftfield, Patricia G Wolf, Yunhu Wan, Andrew Warner and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Doratha A ByrdDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Maria F GomezDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Stephanie R HogueNon-Therapeutic Research Office, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.ORCID https://orcid.org/0000-0002-5677-3518
Jessica R BurnsNon-Therapeutic Research Office, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Nate SmithDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Joshua SampsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Rockville, Maryland, USA.
Erikka LoftfieldDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Rockville, Maryland, USA.
Patricia G WolfDepartment of Nutrition Science, Purdue University, West Lafayette, Indiana, USA.
Yunhu WanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Rockville, Maryland, USA.
Andrew WarnerLeidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Belynda HicksDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Rockville, Maryland, USA.
Casey DagnallDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Rockville, Maryland, USA.
Kristine JonesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Rockville, Maryland, USA.
Youngchul KimDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
Jin XuDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
Jianxin ShiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Rockville, Maryland, USA.
Rashmi SinhaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Rockville, Maryland, USA.
Emily VogtmannDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0000-0003-1355-5593

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Moffitt Cancer Center P30 CA 076292NCI NIH HHS P30 CA076292
6 · The paper itself

Abstract

objectiveThe gut microbiome and bile acids (BAs) likely influence colorectal cancer (CRC) development and disparities. We conducted a nested case-control study of the associations of the colon tissue microbiome and circulating BAs with colorectal adenoma prevalence in the previously conducted multi-center Colorectal Neoplasia Screening with Colonoscopy in Average-Risk Women Regional Navy/Army Medical Centers study (CONCeRN).

methodsWe individually matched 143 women with adenoma to 279 without adenoma. Using 16S rRNA gene sequencing, we assessed alpha and beta diversity, taxonomic abundance, and co-abundance groups (CAGs). Fasting serum was analyzed for 13 primary and secondary BAs.

resultsThe presence of oral-originating Porphyromonas was positively associated with adenomas (odds ratio [OR] and 95% confidence interval [CI] = 2.50 [1.18, 5.30]; p = 0.02). Race and study center explained statistically significant percentages of variation in the beta diversity matrices. BAs were generally positively associated with adenomas, though these results were not statistically significant. DISCUSSION: Overall, our findings suggest the colon tissue microbiome may differ by race and geography, and that certain oral-originating bacteria may be positively associated with adenomas.

Indexed as

AdenomaBile Acids and SaltsColonColorectal NeoplasmsGastrointestinal MicrobiomeAdultAgedCase-Control StudiesFemaleHumansMiddle AgedRisk FactorsRNA, Ribosomal, 16SBile Acids and SaltsRNA, Ribosomal, 16Sadenomaalpha diversitymicrobiome

Identifiers

PMID40937639
PMCPMC12426762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.