Evidence map›Paper›PMID 40937566›Full record

ArticleInternational journal of molecular medicine2025

Mechanosensor Piezo1‑mediated smooth muscular cell pyroptosis contributes to vascular calcification.

Jun Tao, Daiting You, Zejiang Feng, Huangjing Li, Yao Zhang, Yuting Cui, Kaiyuan Lin, Bin Luo, Shengli Yin, Hongmei Tan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jun Tao *Department of Pathophysiology, School of Medicine, Shenzhen Campus of Sun Yat‑sen University, Shenzhen, Guangdong 518107, P.R. China.
Daiting You *Department of Pathophysiology, School of Medicine, Shenzhen Campus of Sun Yat‑sen University, Shenzhen, Guangdong 518107, P.R. China.
Zejiang FengDepartment of Pathophysiology, School of Medicine, Shenzhen Campus of Sun Yat‑sen University, Shenzhen, Guangdong 518107, P.R. China.
Huangjing LiDepartment of Pathophysiology, School of Medicine, Shenzhen Campus of Sun Yat‑sen University, Shenzhen, Guangdong 518107, P.R. China.
Yao ZhangDepartment of Pathophysiology, Zhongshan School of Medicine, Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China.
Yuting CuiDepartment of Pathophysiology, Zhongshan School of Medicine, Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China.
Kaiyuan LinDepartment of Pathophysiology, Zhongshan School of Medicine, Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China.
Bin LuoDepartment of Forensic Medicine, Zhongshan School of Medicine, Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China.
Shengli YinDepartment of Cardiac Surgery, Hui Ya Hospital of The First Affiliated Hospital, Sun Yat‑sen University, Huizhou, Guangdong 516081, P.R. China.
Hongmei TanDepartment of Pathophysiology, School of Medicine, Shenzhen Campus of Sun Yat‑sen University, Shenzhen, Guangdong 518107, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular calcification is a pathological consequence of chronic inflammation and phenotypic switching in smooth muscle cells (SMCs). However, the mechanisms underlying vascular calcification remain unclear. The present study explores the role of the mechanosensor channel, Piezo1, in regulating vascular SMC (VSMC) death and vascular calcification. The findings of the present study demonstrated that Piezo1 expression is upregulated in the atherosclerotic plaques of both mice and patients.

Indexed as

Ion ChannelsMechanotransduction, CellularMuscle, Smooth, VascularMyocytes, Smooth MusclePyroptosisVascular CalcificationAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Core Binding Factor Alpha 1 SubunitHumansMaleMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinCalcium-Calmodulin-Dependent Protein Kinase Type 2Core Binding Factor Alpha 1 SubunitIon ChannelsNLR Family, Pyrin Domain-Containing 3 ProteinPIEZO1 protein, humanPiezo1 protein, mousearterial calcificationcalcium/calmodulin dependent protein kinase IINLR family pyrin domain containing 3Piezo1pyroptosisvascular smooth muscle cells

Identifiers

PMID40937566
PMCPMC12440271

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.