Evidence map›Paper›PMID 40937520›Full record

Observational studyJournal of cachexia, sarcopenia and muscle2025

Association of Diaphragm Involvement Assessed by Ultrasound With Disease Severity in Facioscapulohumeral Muscular Dystrophy.

Xiang Xu, Fuze Zheng, Xin Lin, Liangliang Qiu, Long Chen, Jing Xu, Li Kang, Jie Chen, Liulei Wu, Ying Zheng and 9 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Xiang XuDepartment of Ultrasound, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Fuze ZhengDepartment of Neurology and Institute of Neurology of the First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Xin LinDepartment of Neurology and Institute of Neurology of the First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Liangliang QiuDepartment of Neurology and Institute of Neurology of the First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Long ChenDepartment of Neurology and Institute of Neurology of the First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Jing XuDepartment of Ultrasound, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Li KangDepartment of Ultrasound, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Jie ChenDepartment of Ultrasound, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Liulei WuDepartment of Ultrasound, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Ying ZhengDepartment of Neurology and Institute of Neurology of the First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Minghui ZengDepartment of Neurology and Institute of Neurology of the First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Xiaodan LinDepartment of Neurology and Institute of Neurology of the First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Qifang HeDepartment of Neurology and Institute of Neurology of the First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Li ChenDepartment of Respiratory and Critical Care Medicine Pulmonary Function Test Center, Respiratory Disease Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Feng LinDepartment of Neurology and Institute of Neurology of the First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Ning WangDepartment of Neurology and Institute of Neurology of the First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Minting LinDepartment of Neurology and Institute of Neurology of the First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Guorong LyuDepartment of Ultrasound, the Second Affiliated Hospital, Fujian Medical University, Quanzhou, China.
Zhiqiang WangDepartment of Neurology and Institute of Neurology of the First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.ORCID 0000-0003-2796-6318

Funding

Leading Project Foundation of Science and Technology of Fujian Province 2020Y0024Local Science and Technology Development Project 2022L3011Major Scientific Research Program for Young and Middle-aged Health Professionals of Fujian Province 2023ZQNZD004National Natural Science Foundation of China 82302089National Natural Science Foundation of China 82371409
6 · The paper itself

Abstract

backgroundRespiratory involvement is a comorbidity that should not be overlooked in clinical practice in facioscapulohumeral muscular dystrophy type 1 (FSHD1), with a reported association for severe disease outcomes such as wheelchair dependency. However, patients with FSHD1 can have inaccurate ventilatory function assessment results, owing to facial muscle involvement. Additionally, the association between diaphragm involvement and disease severity in FSHD1 patients remains uncertain. This study aims to assess diaphragm involvement using ultrasound technology and to assess potential associations of diaphragm involvement with respiratory involvement and disease severity.

methodsThis prospective, observational, case-control study enrolled genetically confirmed FSHD1 patients from the Chinese FSHD1 cohort and control participants (matched with FSHD1 patients at a ratio of 2:1 based on gender, age at examination and height) between January 2021 and February 2025. Ultrasound examination of the diaphragm and pulmonary function tests were performed to evaluate respiratory involvement in both FSHD1 patients and paired controls.

resultsThe final analytical sample included 109 patients: 81 patients (median [IQR] age, 33 [23-43] years; 33 [40.7%] female) and 162 control participants (median [IQR] age, 31 [23-45] years; 66 [40.7%] woman) in the exploration cohort, and 28 patients in the validation cohort. Ultrasound parameters of the right hemidiaphragm for diaphragm excursion velocity (V

conclusionsUltrasound parameters, including V

Indexed as

DiaphragmMuscular Dystrophy, FacioscapulohumeralAdultCase-Control StudiesFemaleHumansMaleMiddle AgedProspective StudiesRespiratory Function TestsSeverity of Illness IndexUltrasonographyYoung Adultdiaphragm involvementdisease severityfacioscapulohumeral muscular dystrophy type 1 (FSHD1)respiratory involvementultrasound

Identifiers

PMID40937520
PMCPMC12426622

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.