SynthesisJournal of cachexia, sarcopenia and muscle2025
Enhancing Muscle Quality: Exploring Leucine and Whey Protein in Sarcopenic Individuals.
Synthesis in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A narrative review of nutritional components, health effects, and disease prevention mechanisms of dairy products.Frontiers in public health · 2026Pooled it
- Enhancing Muscle Quality: Exploring Leucine and Whey Protein in Sarcopenic Individuals.Journal of cachexia, sarcopenia and muscle · 2025Pooled it
- Divergent amino acid profiles in sarcopenic obesity versus non-obese sarcopenia: A prospective cohort study in community-dwelling older adults.The journal of nutrition, health & aging · 2026Article
- Distribution of Muscle Mass and Fat Mass to Identify the Risk of Sarcopenia and Sarcopenic Obesity in Adults via Machine Learning.Healthcare (Basel, Switzerland) · 2026Article
- Parthenolide Attenuates Skeletal Muscle Atrophy Through Regulation of Protein Homeostasis and Inhibition of Inflammation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- The Muscle Function Deficit Concept and Inflammaging.Biomedicines · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSarcopenia is characterised by a decline in the skeletal muscle mass with increasing age. This poses many challenges to the health and independence of older individuals. New and emerging studies have focused on supplementing leucine-enriched whey protein and resistance training in older adults to mitigate the effects of sarcopenia, including significant muscle mass loss.
methodsThis study aimed to comprehensively analyse the current literature regarding the beneficial effects of leucine-enriched whey protein supplementation in older adults. This article systematically reviewed randomised controlled trials, longitudinal studies, and meta-analyses published between 2011 and 2024. The biochemical mechanisms underlying the anabolic properties of leucine, including its role in protein synthesis and mTOR signalling pathways, were explored to elucidate its potential to enhance muscle protein accretion.
resultsFindings from the reviewed studies indicate that the combined intervention of leucine-enriched whey protein supplementation and resistance training elicits favourable outcomes regarding increased lean muscle mass, muscle strength and physical performance in older adults with sarcopenia. The potential of leucine-enriched whey protein to mitigate muscle protein breakdown is discussed along with its potential synergistic effects with resistance exercise to optimise muscle adaptation. Future research directions, including investigations of optimal dosing regimens, long-term sustainability and potential contraindications, are proposed to enhance the precision and applicability of this intervention strategy.
conclusionLeucine-enriched whey protein supplementation combined with resistance training is beneficial in addressing sarcopenia in older adults. This review consolidates the current understanding of this intervention, highlights its potential benefits and provides insights for future research and clinical applications in geriatric muscle health.
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