ArticleFrontiers in endocrinology2025
Association between sensitivity to thyroid hormone and prognosis in septic patients: a retrospective cohort analysis.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Early levothyroxine sodium administration and clinical outcomes in patients with sepsis: a MIMIC-IV database analysis.Scientific reports · 2026Article
- Determinants of fatal outcome in septic shock patients with euthyroid sick syndrome.World journal of critical care medicine · 2026Article
- Free Thyroxine as a Predictor of Mortality in Critically Ill Septic Patients-A Retrospective Study.Diagnostics (Basel, Switzerland) · 2026Article
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Authors and funding
11 authors.
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Abstract
Purpose: Sepsis is associated with significant endocrine dysfunction, particularly in thyroid hormone metabolism. This study aims to investigate the association between thyroid hormone sensitivity indices and prognosis in sepsis, exploring their potential as early prognostic markers. Methods: We conducted a retrospective analysis of sepsis patients admitted to the Affiliated Hospital of Guangdong Medical University. Nonlinear associations between thyroid hormones (FT3, FT4, TSH), sensitivity indices (FT3/FT4, TFQI, PTFQI, TSHI, TT4RI), and sepsis mortality were assessed using restricted cubic spline models. Kaplan-Meier curves along with Cox proportional hazards models were used to investigate the longitudinal associations. K-means clustering was applied to thyroid hormone profiles to identify distinct phenotypes. Results: Among 2,391 sepsis patients, non-survivors exhibited significantly lower levels of thyroid hormone and sensitivity indices compared to survivors. Restricted cubic spline analysis revealed a nonlinear dose-response relationship, with lower FT3, TFQI, PTFQI, TSHI, and TT4RI levels associated with increased mortality risk. Multiple Cox regression models identified FT3 (HR = 0.95, 95% CI: 0.93-0.98, Conclusion: Impaired thyroid hormone sensitivity are significantly associated with increased mortality in sepsis, emphasizing their potential as prognostic biomarkers and suggest their utility in risk stratification and personalized management of sepsis patients.
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