Evidence map›Paper›PMID 40937402›Full record

ArticleFrontiers in endocrinology2025

Corneal stromal microdots accumulation and its association with corneal neurodegeneration and retinal microvascular perfusion in diabetes.

Jingrao Wang, Shu Wang, Hong Zhang, Xin Jin

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jingrao WangEye Hospital, The First Affiliated Hospital of Harbin Medical University, Key Laboratory of Basic and Clinical Research of Heilongjiang Province, Harbin, Heilongjiang, China.
Shu WangEye Hospital, The First Affiliated Hospital of Harbin Medical University, Key Laboratory of Basic and Clinical Research of Heilongjiang Province, Harbin, Heilongjiang, China.
Hong ZhangEye Hospital, The First Affiliated Hospital of Harbin Medical University, Key Laboratory of Basic and Clinical Research of Heilongjiang Province, Harbin, Heilongjiang, China.
Xin JinEye Hospital, The First Affiliated Hospital of Harbin Medical University, Key Laboratory of Basic and Clinical Research of Heilongjiang Province, Harbin, Heilongjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The purpose of the study was to investigate the deposition of microdots in corneal stroma in diabetes mellitus (DM) patients and assess the relationship between microdots and corneal nerve damage as well as retinal microvascular perfusion. Methods: 127 patients with DM and 36 age and sex-matched controls were included. All subjects were examined by Results: The deposition of microdots was significantly increased in corneal stroma in patients with DM than controls ( Conclusion: Patients with DM demonstrated a significant increase of deposition of microdots in corneal stroma which correlates with corneal nerve loss and retinal microvascular perfusion. Microdots are at least partially composed of lipofuscin which is also observed in corneal basal epithelial layer.

Indexed as

CorneaCorneal DiseasesCorneal StromaRetinal VesselsAdultAgedCase-Control StudiesDiabetic RetinopathyFemaleHumansMaleMicroscopy, ConfocalMicrovesselsMiddle AgedTomography, Optical Coherencediabetes mellitus (DM)in vivo confocal microscopy (IVCM)lipofuscinmicrodotsoptical coherence tomography angiography (OCTA)

Identifiers

PMID40937402
PMCPMC12421287

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.