ArticleIndian journal of clinical biochemistry : IJCB2025
Low Vitamin A Status: A Potential Limiting Factor for Hemoglobin Improvement to Iron-Folic Acid Supplementation in Adolescent Girls with Iron Deficiency Anemia.
Article in Indian journal of clinical biochemistry : IJCB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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5 authors.
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Abstract
Iron deficiency anemia (IDA) is a persistent public health challenge in India, particularly among adolescent girls. Despite the use of Iron-Folic Acid (IFA) intervention, the IDA prevalence remains high due to variability in the degree of hemoglobin (Hb) response to supplementation. This study aimed to investigate whether the baseline levels of vitamin-A and pro-inflammatory cytokines influence the Hb increase following IFA supplementation in adolescent girls with IDA. Blood samples were collected from girls aged 15-19 y at baseline (day-0) and after 3 months of supplementation (day-90). The Hb was estimated using an analyzer, serum levels of ferritin, TfR, hepcidin, IL-6, TNF-α were measured using ELISA and vitamin A was estimated using HPLC. Based on the change in Hb (day-0-day-90), the response was categorized as good (≥ 1.0 g/dL) and inadequate (< 1.0 g/dL). Nearly 50% IDA subjects exhibited inadequate Hb increment. This group had elevated IL6 levels and decreased vitamin-A levels compared to the good Hb response at baseline (
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