Evidence map›Paper›PMID 40937385›Full record

ArticleIndian journal of clinical biochemistry : IJCB2025

Analysis of Specific Serum Markers for Early Prediction of Alzheimer's Disease in Adolescents with Down Syndrome.

Nagwa A Meguid, Maha Hemimi, Gina Elpatrik, Enas A Fouad-Elhady, Ahmed A Dardir, Hanaa H Ahmed

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of clinical biochemistry : IJCB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Blood-based biomarkers for Alzheimer's disease in Down syndrome: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nagwa A MeguidResearch on Children with Special Needs Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Giza, Egypt.
Maha HemimiResearch on Children with Special Needs Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Giza, Egypt.
Gina ElpatrikResearch on Children with Special Needs Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Giza, Egypt.
Enas A Fouad-ElhadyBiochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Ahmed A DardirResearch on Children with Special Needs Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Giza, Egypt.
Hanaa H AhmedHormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Giza, Egypt.ORCID 0000-0001-8642-9251

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Down syndrome (DS) is accompanied by cognitive manifestations resulting from full or partial extra chromosome 21. Amyloid precursor protein overexpression and the exponential aggregation of amyloid beta in the brain cause dementia in individuals with DS. This study aimed to uncover early serum marker candidates of amyloid precursor protein-like protein 1 beta species denoted APL1β25, APL1β27 and APL1β28 and the noradrenergic metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) as predictors of Alzheimer's disease (AD) in adolescents with DS and to elucidate the correlation between these parameters and the cognition of DS patients. This study included 30 DS cases (13-18 years old) with full trisomy 21 in addition to 30 healthy age-matched controls. The cognitive decline in DS subjects was evaluated using the short form of the Informant Questionnaire on Cognitive Decline in the Elderly (Short IQCODE). Serum levels of APL1b25, ALP1b27, ALP1b28 and MHPG were evaluated using enzyme-linked immunosorbent assay. The results indicated a significant positive correlation (

Indexed as

AdolescentsAlzheimer's diseaseAmyloid precursor proteinDown syndromeNoradrenaline

Identifiers

PMID40937385
PMCPMC12420525

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.