Evidence map›Paper›PMID 40937375›Full record

ArticleJournal of biological methods2025

An experimental workflow for investigating anoikis resistance in cancer metastasis.

Xue Han, Yipan Zheng, Xiaohui Si, Zhe Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biological methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xue HanZhejiang Key Laboratory of Medical Epigenetics, School of Medicine, Hangzhou Normal University, Hangzhou 311121, China.
Yipan ZhengZhejiang Key Laboratory of Medical Epigenetics, School of Medicine, Hangzhou Normal University, Hangzhou 311121, China.
Xiaohui SiZhejiang Key Laboratory of Medical Epigenetics, School of Medicine, Hangzhou Normal University, Hangzhou 311121, China.
Zhe LiuZhejiang Key Laboratory of Medical Epigenetics, School of Medicine, Hangzhou Normal University, Hangzhou 311121, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Anoikis is a form of programmed cell death triggered by the detachment of cells from the extracellular matrix. Anoikis resistance represents a critical factor in tumor metastasis, and elucidating the mechanisms by which epithelial cancer cells evade this process may provide a molecular insight for effectively targeting metastatic progression. Methods: Presented here are an experimental workflow and a detailed protocol to examine anoikis sensitivity in tumor cells both Conclusion: This protocol offers valuable insights into the mechanisms underlying anoikis resistance and may facilitate the identification of novel therapeutic targets for cancer treatment.

Indexed as

Anoikis resistanceCancer metastasisCirculating tumor cell assayThree-dimensional spheroid culture

Identifiers

PMID40937375
PMCPMC12422110

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.