Evidence map›Paper›PMID 40937335›Full record

ArticleEnvironmental epigenetics2025

Epigenome-wide association study of placental co-methylated regions in newborns for prenatal opioid exposure.

Mandy Meijer, Chaini Konwar, Rebecca Asiimwe, Julia Maclsaac, Katia Ramadori, David Lin, Eric L Garland, Brendan Ostlund, Michael S Kobor, Sheila E Crowell and 1 more

Abstract read
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In one paragraph

Article in Environmental epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mandy MeijerDepartment of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.ORCID https://orcid.org/0000-0002-9307-0643
Chaini KonwarDepartment of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
Rebecca AsiimweDepartment of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.ORCID https://orcid.org/0009-0002-1285-1614
Julia MaclsaacDepartment of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
Katia RamadoriDepartment of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
David LinDepartment of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
Eric L GarlandDepartment of Psychiatry, University of California San Diego, San Diego, CA 92093, United States.
Brendan OstlundDepartment of Psychology, Pennsylvania State University, State College, PA 16802, United States.
Michael S KoborDepartment of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
Sheila E CrowellDepartment of Psychology, University of Oregon, Eugene, OR 97403, United States.
Elisabeth ConradtDepartment of Psychology, University of Utah, Salt Lake City, UT 84112, United States.

Funding

Emotion dysregulation across generations: Identifying early developmental and clinical indicators of riskR01MH119070 · NIMH · UNIVERSITY OF UTAH · PI CONRADT, LIZ D, CROWELL, SHEILA E. · 2019 to 2023
$3.9M
Advancing the science and technology of prenatal programing researchR21MH109777 · NIMH · UNIVERSITY OF UTAH · PI CROWELL, SHEILA E. · 2016 to 2017
$384k
NIMH NIH HHS R01 MH119070NIMH NIH HHS R21 MH109777
6 · The paper itself

Abstract

The increasing incidence of opioid use during pregnancy has led to a rise in the number of infants exposed to opioids in utero. Prenatal opioid exposure may have consequences for health and (neuro)development, including neonatal opioid withdrawal syndrome (NOWS). It is unknown which infants are at greatest risk for NOWS. DNA methylation (DNAm) is an epigenetic mark reflecting both allelic variation and environmental exposures, which may provide biomarkers for prenatal opioid exposure and infant NOWS. The placenta is an accessible, biologically relevant tissue in which to directly investigate the epigenetic effects of prenatal opioid exposure. Therefore, the aims of this study were to examine whether prenatal opioid exposure is associated with differential DNAm, including epigenetic age acceleration (EAA) in the placenta. We performed an epigenome-wide association study based on co-methylated regions and single CpG sites in placental samples from in utero opioid-exposed (

Indexed as

co-methylated regionDNA methylationgenetic predispositionneonatal opioid withdrawal syndromeopioidplacentaprenatal opioid exposure

Identifiers

PMID40937335
PMCPMC12422002

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.