Evidence map›Paper›PMID 40937314›Full record

ArticleMediterranean journal of hematology and infectious diseases2025

Predisposing Factors to Infections in Thalassemia Syndrome Patients.

Eman M Mansory, Lina M Abdulrahman, Balsam Osman, Sawsan M Alsiyoufi, Assil F Ruckn, Marwa Aljedaani, Nemmat Hassan, Ahmed S Barefah, Hatem M Alahwal, Yassir Daghistani and 3 more

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Article in Mediterranean journal of hematology and infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Eman M MansoryHematology Department, Faculty of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia.
Lina M AbdulrahmanCollege of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Balsam OsmanCollege of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Sawsan M AlsiyoufiCollege of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Assil F RucknCollege of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Marwa AljedaaniCollege of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Nemmat HassanCollege of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Ahmed S BarefahHematology Department, Faculty of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia.
Hatem M AlahwalHematology Department, Faculty of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia.
Yassir DaghistaniDepartment of Medicine, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia.
Salem M BahashwanHematology Department, Faculty of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia.
Abdullah T AlmohammadiJohns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.
Osman O RadhwiHematology Department, Faculty of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Thalassemia is an inherited blood disorder characterized by abnormal hemoglobin production, leading to chronic anemia. Patients, particularly those who are transfusion-dependent, face a heightened risk of infections due to disease-related factors like anemia and treatment-related complications such as iron overload and splenectomy. This study explores the factors contributing to infections in thalassemia patients to improve management strategies. Methods: A retrospective analysis was conducted on 303 patients with thalassemia at a tertiary care center from 2007 to 2022. Data were collected on demographics, transfusion dependency, splenectomy status, ferritin levels, vaccination history, and Results: Out of 303 patients, 72 (23.8%) experienced culture-positive infections, with Escherichia coli being the most isolated pathogen. Patients with infections had significantly higher ferritin levels and were less likely to be on chelation therapy. Chelation therapy was significantly associated with a reduced risk of infection (OR 0.18, Conclusion: This study highlights the strong link between iron overload, chelation, and risk of infection in thalassemia patients. Effective management, including proper chelation therapy and monitoring ferritin levels, is critical for reducing infections and improving outcomes. Further studies are needed to confirm these findings and guide future management strategies.

Indexed as

InfectionsIron overloadSaudi ArabiaThalassemia

Identifiers

PMID40937314
PMCPMC12422254

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.