ArticleEndocrine oncology (Bristol, England)2025
Efficacy of systemic therapy in metastatic adrenocortical carcinoma: a meta-analysis of prospective clinical trials.
Article in Endocrine oncology (Bristol, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate pooled prospective trial data investigating efficacy of systemic therapies in metastatic adrenocortical carcinoma (mACC), incorporating subgroup analyses by treatment modality and line, establishing survival and response benchmarks. Methods: Prospective trials of systemic therapy regimens in mACC published from 2010 to July 2023 were included. Primary endpoints were overall survival (OS), progression-free survival (PFS), and objective response rates (ORRs). ORR was logit-transformed and pooled using a random effects model and inverse variance method. Kaplan-Meier curves for PFS and OS were digitised, and summary curves were constructed using a multivariate extension of the DerSimonian-Laird method. Results: Across twenty-four studies, 880 patients were included: 386 received chemotherapy, 169 immunotherapies, 288 targeted therapies, and 37 other therapies. Treatment settings were first-line (383 patients, 44%), second-line or beyond (471, 54%), and not reported (26, 3%). Pooled ORR was 9.0% (95% CI 6.0-13.2) with moderate heterogeneity ( Conclusion: This analysis establishes contemporary benchmarks for systemic treatments in mACC. While chemotherapy and immunotherapy offer modest survival benefits, the limited effectiveness of targeted therapy highlights the paucity of actionable molecular biomarkers. Future trials should aim to surpass the survival outcomes identified in this analysis.
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Registered trials
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