ArticleCureus2025
Enhancing Radicular Defense: The Impact of Cross-Linking Agents on Antibiofilm Activity and Collagen Integrity With Bioceramic Sealers.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Photodynamic therapy for caries management: mechanisms, applications, and perspectives.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRoot canal treatment requires thorough chemomechanical debridement and three-dimensional obturation for a fluid-tight seal. However, complete eradication of microbial biofilms is difficult due to the complexities of root canal anatomy, limiting irrigant penetration. Photodynamic therapy plays a key role in enhancing antimicrobial efficacy. Bioceramic sealers are commonly used due to their biocompatibility, antibacterial properties, and bioactivity, though their high alkalinity can damage exposed collagen, leading to tooth fracture. Cross-linking of collagen can slow biodegradation and improve dentin strength. Medicinal plants, like AIM AND
objectiveThis study aimed to examine the antibiofilm efficacy of collagen cross‑linking agents and their effects on the integrity of the radicular collagen matrix. METHODOLOGY: Thirty extracted single-rooted human teeth were decoronated to standardize the root length to 12 mm and then prepared using ProTaper rotary files (Dentsply Maillefer, Ballaigues, Switzerland) up to size F3. The specimens were randomly divided into three groups based on the irrigant used (curcumin, chlorhexidine, and saline). Each group was further subdivided based on the evaluation method. In one set of samples,
resultsCurcumin with light activation (Group 1A) demonstrated the highest cycle threshold values (38.20 ± 1.34), indicating superior bacterial reduction, followed by chlorhexidine (25.06 ± 3.11) and saline.
conclusionCurcumin, particularly when photoactivated, exhibits potent antibiofilm effects and protects collagen in root dentin, making it a promising adjunct in endodontic therapy.
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Registered trials
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