Evidence map›Paper›PMID 40937024›Full record

ArticleInternational journal of applied & basic medical research

Resveratrol Alleviates Aflatoxin B1-induced Renal Cortex Oxidative Stress and Apoptosis in Adult Male Albino Rats.

Naglaa A Bayomy, Reda H Elbakary, Nawal Salama Gouda, Marwa S Badawi, Saad Elshafey, Hanan A Elgendy, Awwad Alenezy, Safya E Esmaeel, Eslam K Fahmy, Naglaa Mokhtar

Abstract read
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In one paragraph

Article in International journal of applied & basic medical research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Naglaa A BayomyDepartment of Anatomy, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.
Reda H ElbakaryDepartment of Histology and Cell Biology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Nawal Salama GoudaDepartment of Microbiology, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.
Marwa S BadawiDepartment of Anatomy, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.
Saad ElshafeyDepartment of Anatomy, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.
Hanan A ElgendyDepartment of Anatomy, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.
Awwad AlenezyDepartment of Family and Community Medicine, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.
Safya E EsmaeelDepartment of Physiology, College of Medicine, Northern Border University, Arar, Saudi Arabia.
Eslam K FahmyDepartment of Physiology, College of Medicine, Northern Border University, Arar, Saudi Arabia.
Naglaa MokhtarDepartment of Medical Biochemistry, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Aflatoxin B1 (AFB1) is a mycotoxin generated by the fungi Materials and Methods: Forty adult male albino rats were evenly assigned into four groups: a control group, a group treated with resveratrol at a dosage of 10 mg/kg/day orally for 10 days, a group treated with AFB1 at a dosage of 1.5 mg/kg/day orally for 10 days and a group treated with both resveratrol and AFB1. After 10 days of treatment, renal tissues were processed for biochemical, gene expression, histopathological, and immunohistochemical investigations. Results: Administering resveratrol led to a reduction in serum creatinine, blood urea nitrogen, renal malondialdehyde concentrations, interleukin 6 gene expression, and the immunoreactivity of the proapoptotic protein (Bax). It also restored reduced glutathione levels, increased sirtuin 1 gene expression, and the immunoreactivity of the antiapoptotic protein (Bcl2). Furthermore, resveratrol improved the alterations in the histopathology in AFB1-treated group. Conclusions: Coadministration of resveratrol in AFB1 toxicity exhibited a significant ability to improve renal function through antioxidant, anti-inflammatory, and antiapoptotic mechanisms in experimentally induced renal damage by AFB1.

Indexed as

Aflatoxin B1antioxidantsnephrotoxicityresveratrolsirtuin 1 gene expression

Identifiers

PMID40937024
PMCPMC12422552

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.