ArticleHealth science reports2025
Dissecting Causal Relationships Between Gut Microbiota, Plasma Metabolites and Bladder Cancer: A Two-Step Mendelian Randomization Study.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Dissecting the Gut Microbiota-metabolite-coronary Atherosclerosis Axis: Evidence from Two-sample Mendelian Randomization.Endocrine, metabolic & immune disorders drug targets · 2026Article
- Fecal microbiota transplantation: a novel strategy and challenges in the adjuvant treatment of bladder Cancer.Frontiers in microbiology · 2026Review
- Dissecting Causal Relationships Between Gut Microbiota, Plasma Metabolites and Bladder Cancer: A Two-Step Mendelian Randomization Study.Health science reports · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Previous studies have shown that gut microbiota is associated with bladder cancer. However, the causal relationships and potential mediating factors between the gut microbiota (GM) and bladder cancer (BCa) have not been well defined. Methods: To investigate this, we utilized summary statistics from genome-wide association studies of gut microbiota (Dutch Microbiome Project, Results: Our study revealed that three taxa, Species Bacteroides dorei, Genus Streptococcus Species and Bacteroides salyersiae, were associated with BCa, while no association was found between BCa on these three taxa. Additionally, we identified 5 plasma metabolites that were simultaneously associated with BCa and the above three taxa. Mediation analysis showed that the associations between Species Bacteroides salyersiae and BCa were mediated by N-methylproline and X-19299, accounting for 11.6% and 28.56% of the total effect, respectively. Furthermore, Species Bacteroides dorei, Genus Streptococcus Species and Bacteroides salyersiae potentially affected BCa through 2,3-dihydroxypyridine, N-palmitoyl-sphinganine and N-methylproline, respectively. Conclusions: Overall, our study dissected the causal relationships between GM and BCa, potentially mediated by plasma metabolites. Our study identified potential targets for treatment of bladder cancer.
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