Evidence map›Paper›PMID 40936948›Full record

ReviewRSC advances2025

A two-decade overview of oxadiazole derivatives as promising anticancer agents.

Mo'men Salem, Khaled El-Adl, Ahmed El-Morsy, Hamada S Abulkhair

Abstract readReview
In one paragraph

Review in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mo'men SalemDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Sinai University-Arish branch Arish Egypt.ORCID https://orcid.org/0000-0001-5606-874X
Khaled El-AdlPharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development Cairo Egypt khaled.eladl@hu.edu.eg.ORCID https://orcid.org/0000-0002-8922-9770
Ahmed El-MorsyPharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Boys), Al-Azhar University Nasr City Cairo 11884 Egypt.
Hamada S AbulkhairPharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Boys), Al-Azhar University Nasr City Cairo 11884 Egypt.ORCID https://orcid.org/0000-0001-6479-4573

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the most difficult illnesses that people today must deal with is cancer. It is distinguished by aberrant cell division and growth, which results in the development of tumors and lumps. The heterocyclic nucleus has drawn a lot of interest in the field of chemotherapeutics; moreover, it is essential in medicinal chemistry. Oxadiazole is a nitrogen-oxygen heterocyclic core with five members that exhibits remarkable anticancer properties. Inhibiting different enzymes and growth factors is the mechanism linked to tumor defeat. This review has covered research conducted over the past 20 years as well as their potential applications in drug development as antineoplastic agents, given the significance of oxadiazole and its derivatives in this global panic problem. This review aims to highlight the anticancer properties of 1,3,4-oxadiazole and its derivatives, 1,2,4-oxadiazole.

Identifiers

PMID40936948
PMCPMC12422214

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.