Evidence map›Paper›PMID 40936934›Full record

ArticleFrontiers in immunology2025

Effect of co-vaccination of cattle with RB51 and BCG on vaccine-specific CD4

Haley M Sterle, Ellie J Putz, Mitchell V Palmer, Steven C Olsen, Paola M Boggiatto

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haley M SterleNational Animal Disease Center, Agricultural Research Service (USDA), Ames, IA, United States.
Ellie J PutzNational Animal Disease Center, Agricultural Research Service (USDA), Ames, IA, United States.
Mitchell V PalmerNational Animal Disease Center, Agricultural Research Service (USDA), Ames, IA, United States.
Steven C OlsenNational Animal Disease Center, Agricultural Research Service (USDA), Ames, IA, United States.
Paola M BoggiattoNational Animal Disease Center, Agricultural Research Service (USDA), Ames, IA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: The study presented here compares functional Th1 responses of RB51 + BCG vaccinated cattle to responses of RB51-only and BCG-only vaccinated cattle to evaluate the feasibility of a combined vaccination strategy for controlling both bovine brucellosis and tuberculosis. Results: This work identified that peripheral blood mononuclear cells (PBMC) from RB51 vaccinates proliferate not only in response to stimulation with killed RB51 but also in response to mycobacterial antigen PPDb. Combination vaccinates show significantly more CD4 Discussion/conclusion: Significantly enhanced BCG-specific Th1 responses in combination vaccinates compared to BCG-only vaccinates suggest that combining vaccinations for

Indexed as

BCG VaccineBrucella abortusBrucella VaccineBrucellosis, BovineCD4-Positive T-LymphocytesMycobacterium bovisTuberculosis, BovineAnimalsCattleCoinfectionVaccinationVaccines, AttenuatedBCG VaccineBrucella VaccineVaccines, AttenuatedBCGcattleCD4RB51T helper 1 (IFN-γ)

Identifiers

PMID40936934
PMCPMC12420227

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.