Evidence map›Paper›PMID 40936770›Full record

ArticlePeerJ2025

Insight into the PmrB structures of colistin-resistant Gram-negative bacteria through the multi-template ligand-guided homology modeling and

Nuttapat Anuwongcharoen, Chuleeporn Phanus-Umporn, Chawalit Chatupheeraphat, Kamonlak Weakwiweak, Noramon Kaewsai, Warawan Eiamphungporn

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In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nuttapat AnuwongcharoenDepartment of Community Medical Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
Chuleeporn Phanus-UmpornDepartment of Community Medical Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
Chawalit ChatupheeraphatCenter for Research Innovation and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Nakhon Pathom, Thailand.
Kamonlak WeakwiweakDepartment of Community Medical Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
Noramon KaewsaiDepartment of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
Warawan EiamphungpornDepartment of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing prevalence of colistin-resistant Gram-negative bacteria necessitates the development of novel therapeutic strategies. PmrB, a histidine kinase involved in colistin resistance, represents a promising drug target. However, the absence of experimentally resolved PmrB structures limits structure-based drug design efforts. This study employed a multi-template, ligand-guided homology modeling approach to construct full-length PmrB models for four pathogens:

Indexed as

Anti-Bacterial AgentsBacterial ProteinsColistinDrug Resistance, BacterialGram-Negative BacteriaTranscription FactorsAcinetobacter baumanniiBinding SitesEscherichia coliKlebsiella pneumoniaeLigandsMolecular Docking SimulationMolecular Dynamics SimulationMutagenesisAnti-Bacterial AgentsBacterial ProteinsColistinLigandsPmrB protein, bacteriaTranscription FactorsColistin resistanceHomology modelingMolecular dockingMolecular dynamicsPmrBStructure-based drug design

Identifiers

PMID40936770
PMCPMC12422264

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.