Evidence map›Paper›PMID 40936713›Full record

ArticleFrontiers in oncology2025

New sepsis-associated morbidity and mortality in pediatric oncology patients.

Alicia M Alcamo, Robert B Lindell, Sydney A Sheetz, Steven D Ham, Andrew Strayer, Scott L Weiss, Akira Nishisaki, Neethi P Pinto, Alexis A Topjian, Julie C Fitzgerald

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alicia M Alcamo *Division of Critical Care Medicine, Department of Anesthesia and Critical Care, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Robert B Lindell *Division of Critical Care Medicine, Department of Anesthesia and Critical Care, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Sydney A SheetzDivision of Critical Care Medicine, Department of Anesthesia and Critical Care, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Steven D HamDivision of Critical Care Medicine, Department of Anesthesia and Critical Care, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Andrew StrayerHaverford College, Haverford, PA, United States.
Scott L WeissDivision of Critical Care, Department of Pediatrics, Nemours Children's Health, Wilmington, DE, United States.
Akira NishisakiDivision of Critical Care Medicine, Department of Anesthesia and Critical Care, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Neethi P PintoDivision of Critical Care Medicine, Department of Anesthesia and Critical Care, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Alexis A TopjianDivision of Critical Care Medicine, Department of Anesthesia and Critical Care, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Julie C FitzgeraldDivision of Critical Care Medicine, Department of Anesthesia and Critical Care, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Funding

Neurocognitive Outcomes and the Trajectory of Recovery One-year After Pediatric SepsisK23HD119673 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI Alicia M. Alcamo · 2025 to 2026
$337k
NICHD NIH HHS K23 HD119673
6 · The paper itself

Abstract

Sepsis is a leading cause of morbidity and mortality in children worldwide, yet the development of new morbidity after sepsis has not been clearly defined in high-risk subgroups such as children with cancer. Using the TOPICC (Trichotomous Outcome Prediction in Critical Care) multicenter cohort study dataset, we evaluated whether children with cancer have a higher risk of the composite outcome of death or new morbidity at hospital discharge compared to children without cancer. Among 854 children with sepsis, 88 patients (10.3%) had an underlying cancer diagnosis. Children with cancer were older (median 8.1 vs 3.7 years) and more frequently developed sepsis while in the hospital. The pattern of organ failure differed between groups, with less frequent invasive mechanical ventilation (26.1% vs 49.9%,

Indexed as

critical caremorbidityoncologypediatricssepsis

Identifiers

PMID40936713
PMCPMC12420283

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.