ArticleFrontiers in oncology2025
Isolated hypoxic pelvic perfusion combined with electroporation is a valid alternative to traditional therapies for anal squamous cell carcinoma: a case study.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: We report a series of four patients with HPV-positive squamous cell carcinoma of the anus: two with non-previously treated grade G3 malignancies, and two with relapsing G2 tumors in progression after chemoradiation. Method: Chemo-naive patients were treated with isolated hypoxic pelvic perfusion, whereas the two patients with local recurrences both received isolated hypoxic pelvic perfusion and concomitant reversible electroporation. Results: The two patients without prior therapy showed a complete clinical and pathological response, one after two and one after three therapies. In the two patients with local recurrences, a clinico-pathological complete remission occurred after two isolated perfusions with electroporation. The two techniques combined produce highly effective drug exposure that leads to complete remission; subsequent blood purification by chemofiltration avoids toxic side effects and cumulative toxicity. The therapies caused no side effects affecting quality of life. No recurrences occurred in the observation period of 48, 27, 10 and 8 months. Conclusion: Isolated hypoxic pelvic perfusion with electroporation is an effective, low-toxicity valid alternative to traditional therapies for the treatment of anal squamous cell carcinoma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.