ArticleFrontiers in oncology2025
A rare case report of uterine carcinosarcoma with bilateral ovarian Brenner tumors.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A rare case of uterine carcinosarcoma in a 21-year-old woman with hereditary breast and ovarian cancer syndrome: A case report.Oncology letters · 2026Article
- Uterine carcinosarcoma with concurrent right nephrolithiasis case report.Discover oncology · 2026Article
- Primary malignant Brenner tumor of the ovary: a case report.Frontiers in oncology · 2025Article
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4 authors.
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Abstract
Background: Uterine carcinosarcoma is a rare, highly aggressive malignancy characterized by both carcinomatous and sarcomatous components. Brenner tumors of the ovary are uncommon epithelial neoplasms, usually benign but occasionally coexisting with other pathologies. The co-occurrence of these two entities is extremely rare and poses diagnostic and therapeutic challenges. Methods: We report a case of a 58-year-old female presenting with scant yellowish vaginal discharge. Imaging studies revealed an intrauterine mass. Histopathological analysis of curettage specimens confirmed endometrial malignancy. The patient underwent radical surgical resection followed by histopathological and immunohistochemical analysis. Results: Histopathology confirmed uterine carcinosarcoma comprising high-grade endometrial adenocarcinoma and pleomorphic sarcoma with chondrosarcoma differentiation. Bilateral ovarian Brenner tumors were also identified. Given the aggressive nature of carcinosarcoma, the patient was referred for adjuvant therapy. Conclusion: This case highlights the importance of prompt pathological evaluation in atypical gynecologic presentations. Early diagnosis through histopathology and immunohistochemistry is crucial for managing rare and aggressive tumors such as uterine carcinosarcoma, particularly when coexisting with other uncommon neoplasms like Brenner tumors. Multidisciplinary care and individualized treatment plans are essential for optimizing outcomes.
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