Evidence map›Paper›PMID 40936667›Full record

ReviewSports medicine and health science2025

The role of resistance training in mitigating cancer-induced cachexia: A systematic review.

Jennifer L Horawski, Sara E Fleszar-Pavlovic, Melissa Lopez-Pentecost, Tracy E Crane, Madalyn G Wheeler, Eric Kholodovsky, Thomas M Best

Abstract readReview
In one paragraph

Review in Sports medicine and health science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Two-legged medicine: Exercise-mediated health benefits.Sports medicine and health science · 2025
    Article
  4. Physical Activity, Exerkines, and Their Role in Cancer Cachexia.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jennifer L HorawskiDivision of Sports Medicine, Department of Orthopaedics, University of Miami Miller School of Medicine, Miami, FL, USA.
Sara E Fleszar-PavlovicSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Melissa Lopez-PentecostSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Tracy E CraneDepartment of Medical OncologySylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Madalyn G WheelerSchool of Education and Human Development, University of Miami, Miami, FL, USA.
Eric KholodovskyUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Thomas M BestDivision of Sports Medicine, Department of Orthopaedics, University of Miami Miller School of Medicine, Miami, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cancer induced cachexia, the involuntary loss of lean body mass and adipose tissue, is a debilitating syndrome experienced in up to 80% of all cancer patients. Cachexia is associated with poor treatment outcomes including decreased quality of life, increased risk of infection, disease progression, and mortality. Recent research suggests that exercise interventions may improve cachexia; however, there is a need for comprehensive and systematic review of the literature to evaluate the role of specific interventions on cancer-induced cachexia. Methods: We conducted a systematic review examining the efficacy of physical activity interventions, particularly resistance training, on cancer-induced cachexia outcomes. We searched seven electronic databases (PubMed, Embase, EBSCO, SCOPUS, Web of Science, PsychINFO, Cochrane) for articles published up to September 2023, yielding 7 eligible studies. Results: Sample sizes ranged from 20 to 190 participants per study. Studies included pancreatic ( Conclusions: The science of exercise interventions to improve outcomes in those with cancer-related cachexia is still emerging although progressive resistance training appears to be the most promising countermeasure. Authors encourage the development of high-quality, fully powered randomized controlled trials (RCTs) examining physical exercise interventions aimed at mitigating cancer-induced cachexia.

Indexed as

CachexiaCancerExercisePhysical activity

Identifiers

PMID40936667
PMCPMC12421196

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.