ArticleChemical science2025
Promoting organic nucleation of diclofenac: hydrophobic interfacial interactions drive self-assembly.
Article in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Interfacial Nucleation Pathways Governing Polymorph Selection Revealed by Synchrotron-BasedJournal of the American Chemical Society · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We compare the pH-triggered nucleation of the pharmaceutical diclofenac in bulk solution and at the air-water interface, using a combination of cryo-transmission electron microscopy, surface-specific spectroscopy and microscopy, and molecular dynamics simulations. In solution, simulation data reveal diclofenac forms dynamically ordered, liquid-like pre-nucleation clusters (PNCs), following a nonclassical nucleation pathway. At the air-water interface, nucleation occurs earlier during the titration process. The promoted nucleation is attributed to the interfacial enrichment of protons at this hydrophobic interface, elevated interfacial apparent p
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.