Evidence map›Paper›PMID 40936613›Full record

ReviewChemical science2025

Mechanisms of ionization and of chemical reactions in charged microdroplets.

Dylan T Holden, Brison A Shira, Myles Quinn Edwards, Nicolás M Morato, R Graham Cooks

Abstract readReview
In one paragraph

Review in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Accelerated Chemistry in Microdroplets.Accounts of chemical research · 2026
    Article
  5. Article
  6. Article
  7. Early-stage drug discovery in a new-generation ultrahigh-throughput mass spectrometry platform.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dylan T HoldenDepartment of Chemistry, Purdue University 560 Oval Dr West Lafayette IN 47907 USA cooks@purdue.edu.ORCID https://orcid.org/0000-0002-3957-8307
Brison A ShiraDepartment of Chemistry, Purdue University 560 Oval Dr West Lafayette IN 47907 USA cooks@purdue.edu.ORCID https://orcid.org/0000-0002-5250-5882
Myles Quinn EdwardsDepartment of Chemistry, Purdue University 560 Oval Dr West Lafayette IN 47907 USA cooks@purdue.edu.ORCID https://orcid.org/0009-0004-1836-6868
Nicolás M MoratoPurdue University, Purdue Institute for Cancer Research 201 S University St. West Lafayette IN 47907 USA.ORCID https://orcid.org/0000-0003-0218-407X
R Graham CooksDepartment of Chemistry, Purdue University 560 Oval Dr West Lafayette IN 47907 USA cooks@purdue.edu.ORCID https://orcid.org/0000-0002-9581-9603

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI ANDREW D MESECAR · 1985 to 2026
$43.4M
High throughput infrastructure for reaction screening and bioassaysUH3TR004139 · NCATS · PURDUE UNIVERSITY · PI Robert Graham Cooks · 2024 to 2026
$4.1M
High throughput infrastructure for reaction screening and bioassaysUG3TR004139 · NCATS · PURDUE UNIVERSITY · PI COOKS, ROBERT GRAHAM · 2022 to 2023
$1.8M
NCATS NIH HHS UG3 TR004139NCATS NIH HHS UH3 TR004139NCI NIH HHS P30 CA023168
6 · The paper itself

Abstract

Over the past decade the use of electrospray ionization mass spectrometry (ESI-MS) has been extended from the domain of chemical analysis to that of chemical synthesis. This development was spurred by the observation of reaction acceleration (by as much as 10

Identifiers

PMID40936613
PMCPMC12421432

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.