Evidence map›Paper›PMID 40936396›Full record

ArticleFEBS letters2025

ACSS2 involved in acetyl-CoA synthesis regulates skeletal muscle function.

Mekala Gunasekaran, Gloriana Campos, Natalya M Wells, Khanhlinh Lambuu, Isabelle Draper, Christina A Pacak, Peter B Kang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mekala GunasekaranGreg Marzolf Jr. Muscular Dystrophy Center and Department of Neurology, University of Minnesota Medical School, Minneapolis, MN, USA.
Gloriana CamposGreg Marzolf Jr. Muscular Dystrophy Center and Department of Neurology, University of Minnesota Medical School, Minneapolis, MN, USA.
Natalya M WellsGreg Marzolf Jr. Muscular Dystrophy Center and Department of Neurology, University of Minnesota Medical School, Minneapolis, MN, USA.
Khanhlinh LambuuGreg Marzolf Jr. Muscular Dystrophy Center and Department of Neurology, University of Minnesota Medical School, Minneapolis, MN, USA.
Isabelle DraperMolecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA.
Christina A PacakGreg Marzolf Jr. Muscular Dystrophy Center and Department of Neurology, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-7430-124X
Peter B KangGreg Marzolf Jr. Muscular Dystrophy Center and Department of Neurology, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-4270-7325

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acyl-coenzyme A synthetase short-chain family member-2 (ACSS2) catalyzes the conversion of acetate to acetyl-CoA, regulating cholesterol metabolism. Given the discovery of a muscular dystrophy associated with 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR), a key enzyme in cholesterol synthesis, we studied Acss2 in mice and the orthologous gene AcCoA in flies. Skeletal muscle from Acss2

Indexed as

Acetate-CoA LigaseAcetyl Coenzyme AMuscle, SkeletalAnimalsATP Citrate (pro-S)-LyaseCholesterolDrosophila melanogasterDrosophila ProteinsMiceMice, KnockoutAcetate-CoA LigaseAcetyl Coenzyme AATP Citrate (pro-S)-LyaseCholesterolDrosophila ProteinsACSS2cholesterol metabolismmuscle development

Identifiers

PMID40936396
PMCPMC12519054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.