Evidence map›Paper›PMID 40936369›Full record

ArticleChemistryOpen2025

Development of 5-Amino-2,4,6-triiodoisophthalic Acid Derivatives for Carbamoylation of Amino Acids.

Kousaku Ohkawa, Tracy Nguyen, Chloe Jin, Hemdeep Kaur, Beatrice Mae Malvar, Rebecca Back, Parisa Khosropour, Shuichi Suzuki, Frank P K Hsu, Ichiro Yuki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemistryOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. A diatrizoic acid derivative forResults in chemistry · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kousaku OhkawaDivision of Synthetic Polymers, Institute of High Polymer Research, Faculty of Textile Science and Technology, Shinshu University, Tokida 3-15-1, Ueda, Nagano Prefecture, 386-8567, Japan.ORCID 0000-0001-5199-092X
Tracy NguyenDepartment of Neurological Surgery, University of California, Irvine, 200S Manchester St., Suite 210, Orange, CA, 92868, USA.
Chloe JinDepartment of Neurological Surgery, University of California, Irvine, 200S Manchester St., Suite 210, Orange, CA, 92868, USA.
Hemdeep KaurDepartment of Neurological Surgery, University of California, Irvine, 200S Manchester St., Suite 210, Orange, CA, 92868, USA.
Beatrice Mae MalvarDepartment of Neurological Surgery, University of California, Irvine, 200S Manchester St., Suite 210, Orange, CA, 92868, USA.
Rebecca BackDepartment of Neurological Surgery, University of California, Irvine, 200S Manchester St., Suite 210, Orange, CA, 92868, USA.
Parisa KhosropourAquaTeX Medical, Inc., Irvine, CA, 92617, USA.
Shuichi SuzukiDepartment of Neurological Surgery, University of California, Irvine, 200S Manchester St., Suite 210, Orange, CA, 92868, USA.
Frank P K HsuDepartment of Neurological Surgery, University of California, Irvine, 200S Manchester St., Suite 210, Orange, CA, 92868, USA.
Ichiro YukiDepartment of Neurological Surgery, University of California, Irvine, 200S Manchester St., Suite 210, Orange, CA, 92868, USA.

Funding

Water-based liquid embolic agent for the treatment of vascular rich tumorsR41CA277860 · NCI · AQUATEX MEDICAL, INC. · PI YUKI, ICHIRO · 2023 to 2023
$400k
Japan Society for the Promotion of Science 23K28448National Institute of Health NIH 1R41CA277860-01A1NCI NIH HHS R41 CA277860
6 · The paper itself

Abstract

Herein, 5-amino-2,4,6-triiodoisophthalic acid (ATIIPA) is used as a nucleophile to produce the corresponding 1,3-diesters. Two types of 1,3-diesters, i) diethyl 5-amino-2,4,6-triiodoisophthalate (DEtTIIP) and ii) diacetoxyethyl 5-amino-2,4,6-triiodoisophthalate (DAcOEtTIIP), are mostly prepared in quantitative yields. The 1,3-esters are tested as a carbamoylation agent toward the amino groups of the βAla esters via isocyanation of the 5-amino group. The addition reaction of DEtTIIP-NCO and βAla-OEt yields DEtTIIP:CO-βAla-OEt, and the 1,3-diethyl ester is highly resistant to alkaline hydrolysis due to the steric shielding by the adjacent 2,4,6-iodines, while the α-ethyl ester of the βAla substructure is easily removed. Alkaline hydrolysis of another adduct, DAcOEtTIIP:CO-βAla-O

Indexed as

Amino AcidsPhthalic AcidsEstersHydrolysisMolecular StructureAmino AcidsEstersPhthalic Acidscarbamoylationdi(acetoxyethyl) 5‐amino‐2,4,6‐triiodoisophthalatediethyl 5‐amino‐2,4,6‐triiodoisophthalateradiopaque materialselective deprotection

Identifiers

PMID40936369
PMCPMC12680579

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.